SCOPe 2.04: Domain d2gtka_: 2gtk A:

Lineage for d2gtka_ (2gtk A:)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)
7. Species Human (Homo sapiens) [TaxId:9606] [48525] (85 PDB entries)
   Uniprot P37231 232-505

8. Domain d2gtka_: 2gtk A: [135654]
   automated match to d1fm6d_
   complexed with 208

Details for d2gtka_

PDB Entry: 2gtk, 2.1 Å

PDB Description: structure-based design of indole propionic acids as novel pparag co- agonists

PDB Compounds: (A:) Peroxisome proliferator-activated receptor gamma

SCOPe Domain Sequences for d2gtka_:

Sequence, based on SEQRES records:

>d2gtka_ a.123.1.1 (A:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
esadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfkh
itplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheii
ytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlai
fiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqiv
tehvqllqvikktetdmslhpllqeiykdly

Sequence, based on observed residues (ATOM records):

>d2gtka_ a.123.1.1 (A:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
esadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkkevai
rifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgv
lisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviilsgdrpg
llnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvikkt
etdmslhpllqeiykdly

Timeline for d2gtka_:

• d2gtka_ first appeared in SCOP 1.73, called d2gtka1
  
• d2gtka_ appears in SCOPe 2.03
  
• d2gtka_ appears in SCOPe 2.05
  
• d2gtka_ appears in the current release, SCOPe 2.08