SCOPe 2.07: Domain d1xmid1: 1xmi D:389-672

Lineage for d1xmid1 (1xmi D:389-672)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.12: ABC transporter ATPase domain-like [52686] (25 proteins)
   there are two additional subdomains inserted into the central core that has a RecA-like topology

6. Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain [102378] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117543] (26 PDB entries)
   Uniprot P13569 389-671

8. Domain d1xmid1: 1xmi D:389-672 [115492]
   Other proteins in same PDB: d1xmia2, d1xmib2, d1xmid2
   complexed with atp, mg

Details for d1xmid1

PDB Entry: 1xmi, 2.25 Å

PDB Description: crystal structure of human f508a nbd1 domain with atp

PDB Compounds: (D:) Cystic fibrosis transmembrane conductance regulator

SCOPe Domain Sequences for d1xmid1:

Sequence, based on SEQRES records:

>d1xmid1 c.37.1.12 (D:389-672) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Human (Homo sapiens) [TaxId: 9606]}
ttevvmenvtafweegfgelfekakqnnnnrktsngddslsfsnfsllgtpvlkdinfki
ergqllavagstgagktsllmmimgelepsegkikhsgrisfcsqfswimpgtikeniia
gvsydeyryrsvikacqleediskfaekdnivlgeggitlsggqrarislaravykdadl
ylldspfgyldvltekeifescvcklmanktrilvtskmehlkkadkililhegssyfyg
tfselqnlqpdfssklmgcdsfdqfsaerrnsiltetlrrfsle

Sequence, based on observed residues (ATOM records):

>d1xmid1 c.37.1.12 (D:389-672) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Human (Homo sapiens) [TaxId: 9606]}
ttevvmenvtafweegfgelfedslsfsnfsllgtpvlkdinfkiergqllavagstgag
ktsllmmimgelepsegkikhsgrisfcsqfswimpgtikeniiagvsydeyryrsvika
cqleediskfaekdnivlgeitlsggqrarislaravykdadlylldspfgyldvlteke
ifescvcklmanktrilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklm
gcdsfdqfsaerrnsiltetlrrfsle

Timeline for d1xmid1:

• d1xmid1 first appeared in SCOP 1.71, called d1xmid_
  
• d1xmid1 appears in SCOPe 2.06
  
• d1xmid1 appears in the current release, SCOPe 2.08