PDB entry 7llh

View 7llh on RCSB PDB site
Description: KPC-2 F72Y mutant with acylated imipenem
Class: hydrolase/antibiotic
Keywords: KPC, Carbapenemase, Beta-lactamase, Hydrolase, Antibiotic Resistance, Enzyme, Beta-lactam, antibiotics, HYDROLASE-ANTIBIOTIC complex
Deposited on 2021-02-03, released 2021-05-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbapenem-hydrolyzing beta-lactamase KPC
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla, kpc, kpc1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9F663 (0-259)
      • engineered mutation (42)
    Domains in SCOPe 2.07: d7llha_
  • Chain 'B':
    Compound: Carbapenem-hydrolyzing beta-lactamase KPC
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla, kpc, kpc1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9F663 (0-259)
      • engineered mutation (42)
    Domains in SCOPe 2.07: d7llhb_
  • Heterogens: IM2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7llhA (A:)
vaepfakleqdfggsigvyamdtgsgatvsyraeerfplcssykgflaaavlarsqqqag
lldtpirygknalvpwspisekylttgmtvaelsaaavqysdnaaanlllkelggpaglt
afmrsigdttfrldrwelelnsaipgdardtsspravteslqkltlgsalaapqrqqfvd
wlkgnttgnhriraavpadwavgdktgtcgvygtandyavvwptgrapivlavytrapnk
ddkhseaviaaaarlalegl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7llhB (B:)
vaepfakleqdfggsigvyamdtgsgatvsyraeerfplcssykgflaaavlarsqqqag
lldtpirygknalvpwspisekylttgmtvaelsaaavqysdnaaanlllkelggpaglt
afmrsigdttfrldrwelelnsaipgdardtsspravteslqkltlgsalaapqrqqfvd
wlkgnttgnhriraavpadwavgdktgtcgvygtandyavvwptgrapivlavytrapnk
ddkhseaviaaaarlalegl