PDB entry 7l0e

View 7l0e on RCSB PDB site
Description: Crystal structure of bovine RPE65 in complex with gem-difluoro emixustat and palmitate
Class: hydrolase/inhibitor
Keywords: non-heme iron, beta propeller, isomerohydrolase, isomerase, monotopic membrane protein, HYDROLASE, HYDROLASE-INHIBITOR complex
Deposited on 2020-12-11, released 2021-06-02
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-06-02, with a file datestamp of 2021-05-28.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Retinoid isomerohydrolase
    Species: Bos taurus [TaxId:9913]
    Gene: RPE65
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28175 (Start-532)
      • conflict (340)
    Domains in SCOPe 2.07: d7l0ea_
  • Chain 'B':
    Compound: Retinoid isomerohydrolase
    Species: Bos taurus [TaxId:9913]
    Gene: RPE65
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28175 (Start-532)
      • conflict (340)
    Domains in SCOPe 2.07: d7l0eb_
  • Heterogens: XQ7, FE2, PLM, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7l0eA (A:)
mssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhl
fdgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpdpcknifsrff
syfrgvevtdnalvniypvgedyyactetnfitkvnpetletikqvdlcnyvsvngatah
phiendgtvynigncfgknfsiaynivkipplqadkedpiskseivvqfpcsdrfkpsyv
hsfgltpnyivfvetpvkinlfkflsswslwganymdcfesnetmgvwlhiadkkrkkyi
nnkyrtspfnlfhhintyedheflivdlccwkgfefvynylylanlrenweevkknarka
pqpevrryvlplnidkadtgknlvtlpnttatailcsdetiwlepevlfsgprqafefpq
inyqkyggkpytyayglglnhfvpdrlcklnvktketwvwqepdsypsepifvshpdale
eddgvvlsvvvspgagqkpayllilnakdlsevaraeveinipvtfhglfkks

    Sequence, based on observed residues (ATOM records): (download) 
    >7l0eA (A:)
sqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlfd
gqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcaffrgvevtdnalvni
ypvgedyyactetnfitkvnpetletikqvdlcnyvsvngatahphiendgtvynigncf
siaynivkipplqadkedpiskseivvqfpcsdrfkpsyvhsfgltpnyivfvetpvkin
lfkganymdcfesnetmgvwlhiadkkrkkyinnkyrtspfnlfhhintyedheflivdl
ccwkgfefvynylylanlrenweevkknarkapqpevrryvlplnidkadtgknlvtlpn
ttatailcsdetiwlepevlfsgprqafefpqinyqkyggkpytyayglglnhfvpdrlc
klnvktketwvwqepdsypsepifvshpdaleeddgvvlsvvvspgagqkpayllilnak
dlsevaraeveinipvtfhglfkks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7l0eB (B:)
mssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhl
fdgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpdpcknifsrff
syfrgvevtdnalvniypvgedyyactetnfitkvnpetletikqvdlcnyvsvngatah
phiendgtvynigncfgknfsiaynivkipplqadkedpiskseivvqfpcsdrfkpsyv
hsfgltpnyivfvetpvkinlfkflsswslwganymdcfesnetmgvwlhiadkkrkkyi
nnkyrtspfnlfhhintyedheflivdlccwkgfefvynylylanlrenweevkknarka
pqpevrryvlplnidkadtgknlvtlpnttatailcsdetiwlepevlfsgprqafefpq
inyqkyggkpytyayglglnhfvpdrlcklnvktketwvwqepdsypsepifvshpdale
eddgvvlsvvvspgagqkpayllilnakdlsevaraeveinipvtfhglfkks

    Sequence, based on observed residues (ATOM records): (download) 
    >7l0eB (B:)
sqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlfd
gqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpgvevtdnalvniy
pvgedyyactetnfitkvnpetletikqvdlcnyvsvngatahphiendgtvynigncfg
iaynivkipplqadkedpiskseivvqfpcsdrfkpsyvhsfgltpnyivfvetpvkinl
fganymdcfesnetmgvwlhiadkkrkkyinnkyrtspfnlfhhintyedheflivdlcc
wkgfefvynylylanlrenweevkknarkapqpevrryvlplnidkadtgknlvtlpntt
atailcsdetiwlepevlfsgprqafefpqinyqkyggkpytyayglglnhfvpdrlckl
nvktketwvwqepdsypsepifvshpdaleeddgvvlsvvvspgagqkpayllilnakdl
sevaraeveinipvtfhglfkks