PDB entry 7ct2

View 7ct2 on RCSB PDB site
Description: New Delhi metallo-beta-lactamase 1 (NDM1) mutant - H116Q
Class: hydrolase
Keywords: Apo, HYDROLASE
Deposited on 2020-08-17, released 2020-09-02
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-09-02, with a file datestamp of 2020-08-28.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Metallo beta lactamase NDM-1
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaNDM-1, bla NDM-1, blaNDM1, NDM-1, BANRA_05884, C7V41_28630, D647_p47098, EC13450_007, F3G17_24725, F3G25_28160, FAT93_27680, FBF54_26795, G4V15_28585, G4V17_28970, G4V19_29075, G4V26_28590, NCTC13443_00040, p2146_00143, pCRE380_21, pN11x00042NDM_090, pNDM-SX04_5, pNDM10469_138, SAMEA3531848_05178, SAMEA3729777_05194, TR3_031, TR4_031
    Database cross-references and differences (RAF-indexed):
    • Uniprot E9NWK5 (Start-234)
      • engineered mutation (84)
    Domains in SCOPe 2.07: d7ct2a_
  • Chain 'B':
    Compound: Metallo beta lactamase NDM-1
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaNDM-1, bla NDM-1, blaNDM1, NDM-1, BANRA_05884, C7V41_28630, D647_p47098, EC13450_007, F3G17_24725, F3G25_28160, FAT93_27680, FBF54_26795, G4V15_28585, G4V17_28970, G4V19_29075, G4V26_28590, NCTC13443_00040, p2146_00143, pCRE380_21, pN11x00042NDM_090, pNDM-SX04_5, pNDM10469_138, SAMEA3531848_05178, SAMEA3729777_05194, TR3_031, TR4_031
    Database cross-references and differences (RAF-indexed):
    • Uniprot E9NWK5 (Start-234)
      • engineered mutation (84)
    Domains in SCOPe 2.07: d7ct2b_
  • Chain 'C':
    Compound: Metallo beta lactamase NDM-1
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaNDM-1, bla NDM-1, blaNDM1, NDM-1, BANRA_05884, C7V41_28630, D647_p47098, EC13450_007, F3G17_24725, F3G25_28160, FAT93_27680, FBF54_26795, G4V15_28585, G4V17_28970, G4V19_29075, G4V26_28590, NCTC13443_00040, p2146_00143, pCRE380_21, pN11x00042NDM_090, pNDM-SX04_5, pNDM10469_138, SAMEA3531848_05178, SAMEA3729777_05194, TR3_031, TR4_031
    Database cross-references and differences (RAF-indexed):
    • Uniprot E9NWK5 (Start-234)
      • engineered mutation (84)
    Domains in SCOPe 2.07: d7ct2c_
  • Chain 'D':
    Compound: Metallo beta lactamase NDM-1
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: blaNDM-1, bla NDM-1, blaNDM1, NDM-1, BANRA_05884, C7V41_28630, D647_p47098, EC13450_007, F3G17_24725, F3G25_28160, FAT93_27680, FBF54_26795, G4V15_28585, G4V17_28970, G4V19_29075, G4V26_28590, NCTC13443_00040, p2146_00143, pCRE380_21, pN11x00042NDM_090, pNDM-SX04_5, pNDM10469_138, SAMEA3531848_05178, SAMEA3729777_05194, TR3_031, TR4_031
    Database cross-references and differences (RAF-indexed):
    • Uniprot E9NWK5 (Start-234)
      • engineered mutation (84)
    Domains in SCOPe 2.07: d7ct2d_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7ct2A (A:)
gqqmetgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtd
dqtaqilnwikqeinlpvalavvtqahqdkmggmdalhaagiatyanalsnqlapqegmv
aaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdska
kslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

    Sequence, based on observed residues (ATOM records): (download) 
    >7ct2A (A:)
gdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtddqtaqi
lnwikqeinlpvalavvtqahqdkmggmdalhaagiatyanalsnqlapqegmvaaqhsl
tfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdskakslgnl
gdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7ct2B (B:)
gqqmetgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtd
dqtaqilnwikqeinlpvalavvtqahqdkmggmdalhaagiatyanalsnqlapqegmv
aaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdska
kslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

    Sequence, based on observed residues (ATOM records): (download) 
    >7ct2B (B:)
gdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtddqtaqi
lnwikqeinlpvalavvtqahqdkmggmdalhaagiatyanalsnqlapqegmvaaqhsl
tfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdskakslgnl
gdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7ct2C (C:)
gqqmetgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtd
dqtaqilnwikqeinlpvalavvtqahqdkmggmdalhaagiatyanalsnqlapqegmv
aaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdska
kslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

    Sequence, based on observed residues (ATOM records): (download) 
    >7ct2C (C:)
gdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtddqtaqi
lnwikqeinlpvalavvtqahqdkmggmdalhaagiatyanalsnqlapqegmvaaqhsl
tfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdskakslgnl
gdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7ct2D (D:)
gqqmetgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtd
dqtaqilnwikqeinlpvalavvtqahqdkmggmdalhaagiatyanalsnqlapqegmv
aaqhsltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdska
kslgnlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

    Sequence, based on observed residues (ATOM records): (download) 
    >7ct2D (D:)
gdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtddqtaqi
lnwikqeinlpvalavvtqahqdkmggmdalhaagiatyanalsnqlapqegmvaaqhsl
tfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclikdskakslgnl
gdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr