PDB entry 6ze1

View 6ze1 on RCSB PDB site
Description: human NBD1 of CFTR in complex with nanobody G11a
Class: hydrolase
Keywords: cystic fibrosis, CFTR, nanobodies, allostery, conformational change, HYDROLASE
Deposited on 2020-06-15, released 2021-06-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: XRAY
Resolution: 2.71 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q20BJ8
      • engineered mutation (106)
      • engineered mutation (148)
      • engineered mutation (153)
    Domains in SCOPe 2.07: d6ze1a_
  • Chain 'B':
    Compound: G11a nanobody
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ZE1 (0-End)
    Domains in SCOPe 2.07: d6ze1b1, d6ze1b2
  • Heterogens: ATP, EDO, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ze1A (A:)
sltttevvmenvtafweegfgelfekakqnnnnrktsngddslffsnfsllgtpvlkdin
fkiergqllavagstgagktsllmmimgelepsegkikhsgrisfcpqfswimpgtiken
iifgvsydeyryrsvikacqleediskfpekdntvlgeggitlsggqrarislaravykd
adlylldspfgyldvltekeifescvcklmanktrilvtskmehlkkadkililhegssy
fygtfselqnlqpdfssklmg

    Sequence, based on observed residues (ATOM records): (download) 
    >6ze1A (A:)
ngddslffsnfsllgtpvlkdinfkiergqllavagstgagktsllmmimgelepsegki
khsgrisfcpqfswimpgtikeniifgvsydeyryrsvikacqleediskfpekdntvlg
eggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktril
vtskmehlkkadkililhegssyfygtfselqnlq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ze1B (B:)
qvqlqesgggvvgpggslrlacafsgrtfsdywmawfrqtpgeerdfvaaisrsgittsy
gdfvegrftitrdnakntvnlqmnflkpedtadyycaagtssflrreydywgqgtqvtvs
saaahhhhhhgaaeqkliseedlngaa

    Sequence, based on observed residues (ATOM records): (download) 
    >6ze1B (B:)
qvqlqesgggvvgpggslrlacafsgrtfsdywmawfrqtpgeerdfvaaisrsgittsy
gdfvegrftitrdnakntvnlqmnflkpedtadyycaagtssflrreydywgqgtqvtvs
sa