PDB entry 6xrm

View 6xrm on RCSB PDB site
Description: Crystal structure of human PI3K-gamma in complex with Compound 4
Class: TRANSFERASE/TRANSFERASE inhibitor
Keywords: Phosphoinositide 3-kinase gamma, inhibitor, immunosuppression, cancer, Proteros, TRANSFERASE, TRANSFERASE-TRANSFERASE inhibitor complex
Deposited on 2020-07-13, released 2020-09-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-10-21, with a file datestamp of 2020-10-16.
Experiment type: XRAY
Resolution: 2.88 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6xrma1, d6xrma2, d6xrma3, d6xrma4
  • Heterogens: V81, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xrmA (A:)
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee
wplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvf
veaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapals
skasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkl
tsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatd
plnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsal
dvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfll
krglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvieml
qkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekck
vmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldl
cllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfq
aaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlv

    Sequence, based on observed residues (ATOM records): (download) 
    >6xrmA (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmeqdfvlrvcgr
deylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeewtvslwdcdrkfrvk
irgidipvdltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgall
nlqiycvqllyyvnlllidhrfllrrgeyvlhmwqissfnadkltsatnpdkensmsisi
lldnvraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkw
gqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlh
yllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavile
aylrgcgtamlhdftqqvqviemlqkvtldiksldvssqvisqlkqklenlqnsqlpesf
rvpydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdml
ilqilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstgafkdevl
nhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfge
rvpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpt
skedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlv