PDB entry 6wxc

View 6wxc on RCSB PDB site
Description: Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with potential refurbishing drug Tipiracil
Class: viral protein
Keywords: SARS Corona virus 2, endoribonuclease, refurbishing drug, COVID-19, Structural Genomics, Center for Structural Genomics of Infectious Diseases, CSGID, VIRAL PROTEIN
Deposited on 2020-05-10, released 2020-05-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-05-20, with a file datestamp of 2020-05-15.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Uridylate-specific endoribonuclease
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (4-349)
      • expression tag (2-3)
    Domains in SCOPe 2.07: d6wxca1, d6wxca2, d6wxca3
  • Chain 'B':
    Compound: Uridylate-specific endoribonuclease
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (4-End)
      • expression tag (2-3)
    Domains in SCOPe 2.07: d6wxcb1, d6wxcb2, d6wxcb3
  • Heterogens: CMU, PO4, EDO, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6wxcA (A:)
snamslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafe
lwakrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkptetic
apltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqf
nyykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehiv
ygdfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvid
lllddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypklq

    Sequence, based on observed residues (ATOM records): (download) 
    >6wxcA (A:)
amslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafelw
akrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkpteticap
ltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfny
ykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivyg
dfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidll
lddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypklq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6wxcB (B:)
snamslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafe
lwakrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkptetic
apltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqf
nyykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehiv
ygdfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvid
lllddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypklq

    Sequence, based on observed residues (ATOM records): (download) 
    >6wxcB (B:)
amslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafelw
akrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkpteticap
ltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfny
ykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivyg
dfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidll
lddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypkl