PDB entry 6we7

View 6we7 on RCSB PDB site
Description: HIV Integrase core domain in complex with inhibitor 3-methyl-2-{5-methyl-2-[2-(thiophen-2-yl)ethynyl]-1- benzofuran-3-yl}butanoic acid
Class: transferase/transferase inhibitor
Keywords: Inhibitor, HIV Integrase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2020-04-01, released 2021-04-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-04-07, with a file datestamp of 2021-04-02.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrase
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot F2WR52
      • engineered mutation (83)
      • conflict (107)
      • engineered mutation (137)
    Domains in SCOPe 2.07: d6we7a_
  • Heterogens: TXM, SO4, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6we7A (A:)
gsmhgevdcspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagr
wpvktvhtdngsnftsttvkaacewagikqefgipynpqsqgviesmekelkkiigqvrd
qaehlktavqmavfihnkkrkggiggysagerivdiiatdietke

    Sequence, based on observed residues (ATOM records): (download) 
    >6we7A (A:)
spgiwqldcthlegkvilvavhvasgyieaeviptgqetayfllklagrwpvktvhtdng
snftsttvkaacewagikqefgipekelkkiigqvrdqaehlktavqmavfihnkkrkgg
ysagerivdiiat