PDB entry 6wc8

View 6wc8 on RCSB PDB site
Description: HIV Integrase core domain in complex with inhibitor 2-(5-(3-fluorophenyl)-2-(2-(thiophen-2-yl)ethynyl)-1- benzofuran-3-yl)ethanoic acid
Class: transferase/transferase inhibitor
Keywords: Inhibitor, HIV Integrase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2020-03-29, released 2021-03-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-03-31, with a file datestamp of 2021-03-26.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrase
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot F2WR52
      • engineered mutation (83)
      • engineered mutation (137)
    Domains in SCOPe 2.07: d6wc8a_
  • Heterogens: TQM, IOD, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6wc8A (A:)
gsmhgevdcspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagr
wpvktvhtdngsnftsttvkaacewagikqefgipynpqsqgviesmnkelkkiigqvrd
qaehlktavqmavfihnkkrkggiggysagerivdiiatdietke

    Sequence, based on observed residues (ATOM records): (download) 
    >6wc8A (A:)
spgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtd
ngsnftsttvkaacewagikqefgiesmnkelkkiigqvrdqaehlktavqmavfihnkk
rggysagerivdiiatdi