PDB entry 6wbs

View 6wbs on RCSB PDB site
Description: Human CFTR first nucleotide binding domain with dF508/V510D
Class: hydrolase
Keywords: Ion Channel, ATP Binding, HYDROLASE
Deposited on 2020-03-27, released 2021-04-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-04-07, with a file datestamp of 2021-04-02.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR, ABCC7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (0-End)
      • engineered mutation (89)
    Domains in SCOPe 2.07: d6wbsa_
  • Chain 'B':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR, ABCC7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (Start-225)
      • engineered mutation (89)
    Domains in SCOPe 2.07: d6wbsb_
  • Heterogens: ATP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6wbsA (A:)
tttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmvimgelepse
gkikhsgrisfcsqfswimpgtikeniigdsydeyryrsvikacqleediskfaekdniv
lgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktr
ilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklmg

    Sequence, based on observed residues (ATOM records): (download) 
    >6wbsA (A:)
tttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmvimgelepse
gkikhsgrisfcsqfswimpgtikeniigdsydeyryrsvikacqleediskfaekdniv
lgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktr
ilvtskmehlkkadkililhegssyfygtfselqn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6wbsB (B:)
tttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmvimgelepse
gkikhsgrisfcsqfswimpgtikeniigdsydeyryrsvikacqleediskfaekdniv
lgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktr
ilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklmg

    Sequence, based on observed residues (ATOM records): (download) 
    >6wbsB (B:)
ttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmvimgelepseg
kikhsgrisfcsqfswimpgtikeniigdsydeyryrsvikacqleediskfaekdnivl
geggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktri
lvtskmehlkkadkililhegssyfygtfselqnlqpdfssklmg