PDB entry 6ti3

View 6ti3 on RCSB PDB site
Description: Apo-SHMT from Streptococcus thermophilus Tyr55Ser variant in complex with D-Threonine
Class: transferase
Keywords: Pyridoxal phosphate; X-ray crystallography; hydroxymethyltransferase; proton abstraction; tetrahydrofolate-independent, transferase
Deposited on 2019-11-21, released 2020-04-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-04-29, with a file datestamp of 2020-04-24.
Experiment type: XRAY
Resolution: 1.96 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine hydroxymethyltransferase
    Species: Streptococcus thermophilus [TaxId:1308]
    Gene: glyA, CDA68_00974, DID82_07515
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5MCK9 (Start-415)
      • engineered mutation (54)
    Domains in SCOPe 2.07: d6ti3a_
  • Chain 'B':
    Compound: serine hydroxymethyltransferase
    Species: Streptococcus thermophilus [TaxId:1308]
    Gene: glyA, CDA68_00974, DID82_07515
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5MCK9 (Start-415)
      • engineered mutation (54)
    Domains in SCOPe 2.07: d6ti3b_
  • Chain 'C':
    Compound: serine hydroxymethyltransferase
    Species: Streptococcus thermophilus [TaxId:1308]
    Gene: glyA, CDA68_00974, DID82_07515
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5MCK9 (Start-415)
      • engineered mutation (54)
    Domains in SCOPe 2.07: d6ti3c_
  • Chain 'D':
    Compound: serine hydroxymethyltransferase
    Species: Streptococcus thermophilus [TaxId:1308]
    Gene: glyA, CDA68_00974, DID82_07515
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5MCK9 (Start-415)
      • engineered mutation (54)
    Domains in SCOPe 2.07: d6ti3d_
  • Heterogens: DTH, GOL, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ti3A (A:)
mifdkedykafdpelwnaidaeaerqqnnieliasenvvskavmaaqgtlltnksaegyp
gkryyggtavidvvetlaierakklfgakfanvqphsgsqanaavymsliqpgdtvmgmd
lsagghlthgapvsfsgktynfvsynvdkeselldydailaqakevrpklivagasaysr
iidfakfreiadavgaylmvdmahiaglvasghhpspvpyahvttttthktlrgprggli
ltddediakklnsavfpglqggplehviaakavalkealdpafkeygenviknaaamadv
fnqhpdfrvisggtnnhlflvdvtkvvengkvaqnvleevnitlnknsipyeqlspfkts
girvgspaitsrgmgeaesrqiaewmvealenhdkpevlerirgdvkvltdafply

    Sequence, based on observed residues (ATOM records): (download) 
    >6ti3A (A:)
dykafdpelwnaidaeaerqqnnieliasenvvskavmaaqgtlltnksaegypgkryyg
gtavidvvetlaierakklfgakfanvqphsgsqanaavymsliqpgdtvmgmdlsaggh
lthgapvsfsgktynfvsynvdkeselldydailaqakevrpklivagasaysriidfak
freiadavgaylmvdmahiaglvasghhpspvpyahvttttthktlrgprggliltdded
iakklnsavfpglqggplehviaakavalkealdpafkeygenviknaaamadvfnqhpd
frvisggtnnhlflvdvtkvvengkvaqnvleevnitlnknsipyeqlspfktsgirvgs
paitsrgmgeaesrqiaewmvealenhdkpevlerirgdvkvltdafply

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ti3B (B:)
mifdkedykafdpelwnaidaeaerqqnnieliasenvvskavmaaqgtlltnksaegyp
gkryyggtavidvvetlaierakklfgakfanvqphsgsqanaavymsliqpgdtvmgmd
lsagghlthgapvsfsgktynfvsynvdkeselldydailaqakevrpklivagasaysr
iidfakfreiadavgaylmvdmahiaglvasghhpspvpyahvttttthktlrgprggli
ltddediakklnsavfpglqggplehviaakavalkealdpafkeygenviknaaamadv
fnqhpdfrvisggtnnhlflvdvtkvvengkvaqnvleevnitlnknsipyeqlspfkts
girvgspaitsrgmgeaesrqiaewmvealenhdkpevlerirgdvkvltdafply

    Sequence, based on observed residues (ATOM records): (download) 
    >6ti3B (B:)
dykafdpelwnaidaeaerqqnnieliasenvvskavmaaqgtlltnksaegypgkryyg
gtavidvvetlaierakklfgakfanvqphsgsqanaavymsliqpgdtvmgmdlsaggh
lthgapvsfsgktynfvsynvdkeselldydailaqakevrpklivagasaysriidfak
freiadavgaylmvdmahiaglvasghhpspvpyahvttttthktlrgprggliltdded
iakklnsavfpglqggplehviaakavalkealdpafkeygenviknaaamadvfnqhpd
frvisggtnnhlflvdvtkvvengkvaqnvleevnitlnknsipyeqlspfktsgirvgs
paitsrgmgeaesrqiaewmvealenhdkpevlerirgdvkvltdafply

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6ti3C (C:)
mifdkedykafdpelwnaidaeaerqqnnieliasenvvskavmaaqgtlltnksaegyp
gkryyggtavidvvetlaierakklfgakfanvqphsgsqanaavymsliqpgdtvmgmd
lsagghlthgapvsfsgktynfvsynvdkeselldydailaqakevrpklivagasaysr
iidfakfreiadavgaylmvdmahiaglvasghhpspvpyahvttttthktlrgprggli
ltddediakklnsavfpglqggplehviaakavalkealdpafkeygenviknaaamadv
fnqhpdfrvisggtnnhlflvdvtkvvengkvaqnvleevnitlnknsipyeqlspfkts
girvgspaitsrgmgeaesrqiaewmvealenhdkpevlerirgdvkvltdafply

    Sequence, based on observed residues (ATOM records): (download) 
    >6ti3C (C:)
dykafdpelwnaidaeaerqqnnieliasenvvskavmaaqgtlltnksaegypgkryyg
gtavidvvetlaierakklfgakfanvqphsgsqanaavymsliqpgdtvmgmdlsaggh
lthgapvsfsgktynfvsynvdkeselldydailaqakevrpklivagasaysriidfak
freiadavgaylmvdmahiaglvasghhpspvpyahvttttthktlrgprggliltdded
iakklnsavfpglqggplehviaakavalkealdpafkeygenviknaaamadvfnqhpd
frvisggtnnhlflvdvtkvvengkvaqnvleevnitlnknsipyeqlspfktsgirvgs
paitsrgmgeaesrqiaewmvealenhdkpevlerirgdvkvltdafply

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6ti3D (D:)
mifdkedykafdpelwnaidaeaerqqnnieliasenvvskavmaaqgtlltnksaegyp
gkryyggtavidvvetlaierakklfgakfanvqphsgsqanaavymsliqpgdtvmgmd
lsagghlthgapvsfsgktynfvsynvdkeselldydailaqakevrpklivagasaysr
iidfakfreiadavgaylmvdmahiaglvasghhpspvpyahvttttthktlrgprggli
ltddediakklnsavfpglqggplehviaakavalkealdpafkeygenviknaaamadv
fnqhpdfrvisggtnnhlflvdvtkvvengkvaqnvleevnitlnknsipyeqlspfkts
girvgspaitsrgmgeaesrqiaewmvealenhdkpevlerirgdvkvltdafply

    Sequence, based on observed residues (ATOM records): (download) 
    >6ti3D (D:)
dykafdpelwnaidaeaerqqnnieliasenvvskavmaaqgtlltnksaegypgkryyg
gtavidvvetlaierakklfgakfanvqphsgsqanaavymsliqpgdtvmgmdlsaggh
lthgapvsfsgktynfvsynvdkeselldydailaqakevrpklivagasaysriidfak
freiadavgaylmvdmahiaglvasghhpspvpyahvttttthktlrgprggliltdded
iakklnsavfpglqggplehviaakavalkealdpafkeygenviknaaamadvfnqhpd
frvisggtnnhlflvdvtkvvengkvaqnvleevnitlnknsipyeqlspfktsgirvgs
paitsrgmgeaesrqiaewmvealenhdkpevlerirgdvkvltdafply