PDB entry 6tdq

View 6tdq on RCSB PDB site
Description: Crystal structure of the disulfide engineered HLA-A0201 molecule in complex with one GM dipeptide in the A pocket and one GM dipeptide in the F pocket.
Class: immune system
Keywords: MHC Class I molecule, IMMUNE SYSTEM
Deposited on 2019-11-10, released 2020-03-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-03-25, with a file datestamp of 2020-03-20.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed):
    • Uniprot F6IQS1 (Start-275)
      • conflict (84)
      • conflict (139)
      • conflict (245)
    Domains in SCOPe 2.07: d6tdqa1, d6tdqa2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d6tdqb1, d6tdqb2
  • Chain 'C':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed):
    • Uniprot F6IQS1 (Start-275)
      • conflict (84)
      • conflict (139)
      • conflict (245)
    Domains in SCOPe 2.07: d6tdqc1, d6tdqc2
  • Chain 'D':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d6tdqd1, d6tdqd2
  • Heterogens: CL, EDO, GLY, MET, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6tdqA (A:)
agshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpey
wdgetrkvkahsqthrvdlgtlrgcynqseagshtvqrmygcdvgsdwrflrgyhqyayd
gkdyialkedlrswtaadmcaqttkhkweaahvaeqlraylegtcvewlrrylengketl
qrtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdg
tfqkwvavvvpsgqeqrytchvqheglpkpltlrwe

    Sequence, based on observed residues (ATOM records): (download) 
    >6tdqA (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgcynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmcaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwvavvvpsgqeqrytchvqheglpkpltlrwe

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6tdqB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6tdqC (C:)
agshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpey
wdgetrkvkahsqthrvdlgtlrgcynqseagshtvqrmygcdvgsdwrflrgyhqyayd
gkdyialkedlrswtaadmcaqttkhkweaahvaeqlraylegtcvewlrrylengketl
qrtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdg
tfqkwvavvvpsgqeqrytchvqheglpkpltlrwe

    Sequence, based on observed residues (ATOM records): (download) 
    >6tdqC (C:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgcynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmcaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwvavvvpsgqeqrytchvqheglpkpltlrwe

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6tdqD (D:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm