PDB entry 6t5u

View 6t5u on RCSB PDB site
Description: KRasG12C ligand complex
Class: signaling protein
Keywords: GTPase, SIGNALING PROTEIN
Deposited on 2019-10-17, released 2020-02-19
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-02-19, with a file datestamp of 2020-02-14.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: GTPase KRas isoform X2
  Species: Erinaceus europaeus [TaxId:9365]
  Gene: KRAS
  Database cross-references and differences (RAF-indexed):
  • Uniprot A0A1S2ZE25 (1-167)
    • expression tag (0)
    • engineered mutation (12)
    • conflict (51)
    • conflict (80)
    • conflict (118)
  Domains in SCOPe 2.07: d6t5ua1, d6t5ua2
• Chain 'B':
  Compound: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b
  Species: Homo sapiens [TaxId:9606]
  Gene: KRAS, hCG_14731
  Database cross-references and differences (RAF-indexed):
  • Uniprot A0A024RAV5 (1-166)
    • expression tag (0)
    • conflict (12)
    • conflict (51)
    • conflict (80)
    • conflict (118)
  Domains in SCOPe 2.07: d6t5ub1, d6t5ub2
• Heterogens: MKW, MG, GDP, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6t5uA (A:)
  gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
  gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
  lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6t5uB (B:)
  gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
  gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
  lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh