PDB entry 6smn

View 6smn on RCSB PDB site
Description: A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with methotrexate
Class: transferase
Keywords: SHMT, antifolate, TRANSFERASE
Deposited on 2019-08-22, released 2020-01-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 1.63 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine hydroxymethyltransferase 2, mitochondrial
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: SHM2, SHMT2, At5g26780, F2P16.40
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6smna_
  • Chain 'B':
    Compound: Serine hydroxymethyltransferase 2, mitochondrial
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: SHM2, SHMT2, At5g26780, F2P16.40
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6smnb_
  • Chain 'C':
    Compound: Serine hydroxymethyltransferase 2, mitochondrial
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: SHM2, SHMT2, At5g26780, F2P16.40
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6smnc_
  • Chain 'D':
    Compound: Serine hydroxymethyltransferase 2, mitochondrial
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: SHM2, SHMT2, At5g26780, F2P16.40
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q94C74 (3-479)
      • expression tag (0-2)
    Domains in SCOPe 2.07: d6smnd1, d6smnd2
  • Heterogens: MTX, PLS, EDO, SER, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6smnA (A:)
snaeksrsswikqlnasldeidpevadiielekarqwkgfelipsenftslsvmqavgsv
mtnkysegypgaryyggneyidmaetlcqkraleafqldpskwgvnvqslsgspanfqvy
tallkpherimaldlphgghlshgyqtdtkkisavsiffetmpyrldentgyidydqlek
savlfrpklivagasayarlydyarirkvcnkqkavmladmahisglvaagvipspfeya
dvvtttthkslrgprgamiffrkglkeinkqgkevmydyedrinqavfpglqggphnhti
tglavalkqartpeykayqdqvlrncskfaetllakgydlvsggtdnhlvlvnlknkgid
gsrvekvlelvhiaankntvpgdvsamvpggirmgtpaltsrgfieedfakvaeyfdlav
kialkikaesqgtklkdfvatmqsneklqsemsklremveeyakqfptigfeketmryke

    Sequence, based on observed residues (ATOM records): (download) 
    >6smnA (A:)
srsswikqlnasldeidpevadiielekarqwkgfelipsenftslsvmqavgsvmtnky
segypgaryyggneyidmaetlcqkraleafqldpskwgvnvqslsgspanfqvytallk
pherimaldlphgghlshgyqtdtkkisavsiffetmpyrldentgyidydqleksavlf
rpklivagasayarlydyarirkvcnkqkavmladmahisglvaagvipspfeyadvvtt
tthkslrgprgamiffrkglkeinkqgkevmydyedrinqavfpglqggphnhtitglav
alkqartpeykayqdqvlrncskfaetllakgydlvsggtdnhlvlvnlknkgidgsrve
kvlelvhiaankntvpgdvsamvpggirmgtpaltsrgfieedfakvaeyfdlavkialk
ikaesqgtklkdfvatmqsneklqsemsklremveeyakqfptigfeketmryke

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6smnB (B:)
snaeksrsswikqlnasldeidpevadiielekarqwkgfelipsenftslsvmqavgsv
mtnkysegypgaryyggneyidmaetlcqkraleafqldpskwgvnvqslsgspanfqvy
tallkpherimaldlphgghlshgyqtdtkkisavsiffetmpyrldentgyidydqlek
savlfrpklivagasayarlydyarirkvcnkqkavmladmahisglvaagvipspfeya
dvvtttthkslrgprgamiffrkglkeinkqgkevmydyedrinqavfpglqggphnhti
tglavalkqartpeykayqdqvlrncskfaetllakgydlvsggtdnhlvlvnlknkgid
gsrvekvlelvhiaankntvpgdvsamvpggirmgtpaltsrgfieedfakvaeyfdlav
kialkikaesqgtklkdfvatmqsneklqsemsklremveeyakqfptigfeketmryke

    Sequence, based on observed residues (ATOM records): (download) 
    >6smnB (B:)
srsswikqlnasldeidpevadiielekarqwkgfelipsenftslsvmqavgsvmtnky
segypgaryyggneyidmaetlcqkraleafqldpskwgvnvqslsgspanfqvytallk
pherimaldlphgghlshgyqtdtkkisavsiffetmpyrldentgyidydqleksavlf
rpklivagasayarlydyarirkvcnkqkavmladmahisglvaagvipspfeyadvvtt
tthkslrgprgamiffrkglkeinkqgkevmydyedrinqavfpglqggphnhtitglav
alkqartpeykayqdqvlrncskfaetllakgydlvsggtdnhlvlvnlknkgidgsrve
kvlelvhiaankntvpgdvsamvpggirmgtpaltsrgfieedfakvaeyfdlavkialk
ikaesqgtklkdfvatmqsneklqsemsklremveeyakqfptigfeketmryke

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6smnC (C:)
snaeksrsswikqlnasldeidpevadiielekarqwkgfelipsenftslsvmqavgsv
mtnkysegypgaryyggneyidmaetlcqkraleafqldpskwgvnvqslsgspanfqvy
tallkpherimaldlphgghlshgyqtdtkkisavsiffetmpyrldentgyidydqlek
savlfrpklivagasayarlydyarirkvcnkqkavmladmahisglvaagvipspfeya
dvvtttthkslrgprgamiffrkglkeinkqgkevmydyedrinqavfpglqggphnhti
tglavalkqartpeykayqdqvlrncskfaetllakgydlvsggtdnhlvlvnlknkgid
gsrvekvlelvhiaankntvpgdvsamvpggirmgtpaltsrgfieedfakvaeyfdlav
kialkikaesqgtklkdfvatmqsneklqsemsklremveeyakqfptigfeketmryke

    Sequence, based on observed residues (ATOM records): (download) 
    >6smnC (C:)
srsswikqlnasldeidpevadiielekarqwkgfelipsenftslsvmqavgsvmtnky
segypgaryyggneyidmaetlcqkraleafqldpskwgvnvqslsgspanfqvytallk
pherimaldlphgghlshgyqtdtkkisavsiffetmpyrldentgyidydqleksavlf
rpklivagasayarlydyarirkvcnkqkavmladmahisglvaagvipspfeyadvvtt
tthkslrgprgamiffrkglkeinkqgkevmydyedrinqavfpglqggphnhtitglav
alkqartpeykayqdqvlrncskfaetllakgydlvsggtdnhlvlvnlknkgidgsrve
kvlelvhiaankntvpgdvsamvpggirmgtpaltsrgfieedfakvaeyfdlavkialk
ikaesqgtklkdfvatmqsneklqsemsklremveeyakqfptigfeketmryke

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6smnD (D:)
snaeksrsswikqlnasldeidpevadiielekarqwkgfelipsenftslsvmqavgsv
mtnkysegypgaryyggneyidmaetlcqkraleafqldpskwgvnvqslsgspanfqvy
tallkpherimaldlphgghlshgyqtdtkkisavsiffetmpyrldentgyidydqlek
savlfrpklivagasayarlydyarirkvcnkqkavmladmahisglvaagvipspfeya
dvvtttthkslrgprgamiffrkglkeinkqgkevmydyedrinqavfpglqggphnhti
tglavalkqartpeykayqdqvlrncskfaetllakgydlvsggtdnhlvlvnlknkgid
gsrvekvlelvhiaankntvpgdvsamvpggirmgtpaltsrgfieedfakvaeyfdlav
kialkikaesqgtklkdfvatmqsneklqsemsklremveeyakqfptigfeketmryke