PDB entry 6rh8

View 6rh8 on RCSB PDB site
Description: Revisiting pH-gated conformational switch. Complex HK853 mutant H260A -RR468 mutant D53A pH 5.3
Class: signaling protein
Keywords: Histidine Kinase, Response Regulator, Phosphotransfer, Phosphatase, SIGNALING PROTEIN
Deposited on 2019-04-19, released 2020-02-19
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-02-19, with a file datestamp of 2020-02-14.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: sensor histidine kinase
    Species: Thermotoga maritima [TaxId:2336]
    Gene: TM_0853
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WZV7
      • conflict (28)
    Domains in SCOPe 2.07: d6rh8a1, d6rh8a2
  • Chain 'B':
    Compound: sensor histidine kinase
    Species: Thermotoga maritima [TaxId:2336]
    Gene: TM_0853
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WZV7
      • conflict (28)
    Domains in SCOPe 2.07: d6rh8b1, d6rh8b2
  • Chain 'C':
    Compound: Response regulator
    Species: Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [TaxId:243274]
    Gene: TM_0468
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT9 (Start-121)
      • engineered mutation (52)
    Domains in SCOPe 2.07: d6rh8c_
  • Chain 'D':
    Compound: Response regulator
    Species: Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [TaxId:243274]
    Gene: TM_0468
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT9 (Start-121)
      • engineered mutation (52)
    Domains in SCOPe 2.07: d6rh8d_
  • Heterogens: ADP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6rh8A (A:)
venvteskelerlkridrmktefianisaelrtpltaikayaetiynslgeldlstlkef
leviidqsnhlenllnelldfsrlerkslqinrekvdlcdlvesavnaikefasshnvnv
lfesnvpcpveayidptrirqvllnllnngvkyskkdapdkyvkvildekdggvliived
ngigipdhakdrifeqfyrvdssltyevpgtglglaitkeivelhggriwvesevgkgsr
ffvwipkdragednrqdn

    Sequence, based on observed residues (ATOM records): (download) 
    >6rh8A (A:)
rlkridrmktefianisaelrtpltaikayaetiynslgeldlstlkefleviidqsnhl
enllnelldfsrlerkslqinrekvdlcdlvesavnaikefasshnvnvlfesnvpcpve
ayidptrirqvllnllnngvkyskkdapdkyvkvildekdggvliivedngigipdhakd
rifeqfyrvdssltyevpgtglglaitkeivelhggriwvesevgkgsrffvwipkd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6rh8B (B:)
venvteskelerlkridrmktefianisaelrtpltaikayaetiynslgeldlstlkef
leviidqsnhlenllnelldfsrlerkslqinrekvdlcdlvesavnaikefasshnvnv
lfesnvpcpveayidptrirqvllnllnngvkyskkdapdkyvkvildekdggvliived
ngigipdhakdrifeqfyrvdssltyevpgtglglaitkeivelhggriwvesevgkgsr
ffvwipkdragednrqdn

    Sequence, based on observed residues (ATOM records): (download) 
    >6rh8B (B:)
rlkridrmktefianisaelrtpltaikayaetiynslgeldlstlkefleviidqsnhl
enllnelldfsrlerkslqinrekvdlcdlvesavnaikefasshnvnvlfesnvpcpve
ayidptrirqvllnllnngvkyskkdapdkyvkvildekdggvliivedngigipdhakd
rifeqfyrvdssltyevpgtglglaitkeivelhggriwvesevgkgsrffvwipkd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6rh8C (C:)
mskkvllvddsavlrkivsfnlkkegyevieaengqialeklseftpdlivlaimmpvmd
gftvlkklqekeewkripvivltakggeedeslalslgarkvmrkpfspsqfieevkhll
ne

    Sequence, based on observed residues (ATOM records): (download) 
    >6rh8C (C:)
skkvllvddsavlrkivsfnlkkegyevieaengqialeklseftpdlivlaimmpvmdg
ftvlkklqekeewkripvivltakggeedeslalslgarkvmrkpfspsqfieevkhlln
e

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6rh8D (D:)
mskkvllvddsavlrkivsfnlkkegyevieaengqialeklseftpdlivlaimmpvmd
gftvlkklqekeewkripvivltakggeedeslalslgarkvmrkpfspsqfieevkhll
ne

    Sequence, based on observed residues (ATOM records): (download) 
    >6rh8D (D:)
skkvllvddsavlrkivsfnlkkegyevieaengqialeklseftpdlivlaimmpvmdg
ftvlkklqekeewkripvivltakggeedeslalslgarkvmrkpfspsqfieevkhlln
e