PDB entry 6qyq

View 6qyq on RCSB PDB site
Description: Crystal structure of human thymidylate synthase (hTS) variant R175C
Class: transferase
Keywords: human thymidylate synthase, folate pathway, R175C, interface variant, TRANSFERASE
Deposited on 2019-03-09, released 2019-04-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-04-17, with a file datestamp of 2019-04-12.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (186)
    Domains in SCOPe 2.07: d6qyqa_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (186)
    Domains in SCOPe 2.07: d6qyqb_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (186)
    Domains in SCOPe 2.07: d6qyqc_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (186)
    Domains in SCOPe 2.07: d6qyqd_
  • Heterogens: SO4, CL, FFO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6qyqA (A:)
mrgshhhhhhgsmpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkd
drtgtgtlsvfgmqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvki
wdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidti
ktnpddcriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfnia
syalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkveki
ddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >6qyqA (A:)
eprpphgelqylgqiqhilrcgvrkddtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddcriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmem

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6qyqB (B:)
mrgshhhhhhgsmpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkd
drtgtgtlsvfgmqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvki
wdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidti
ktnpddcriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfnia
syalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkveki
ddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >6qyqB (B:)
prpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkg
vleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfg
aeyrdmesdysgqgvdqlqrvidtiktnpddcriimcawnprdlplmalppchalcqfyv
vnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhie
plkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmema

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6qyqC (C:)
mrgshhhhhhgsmpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkd
drtgtgtlsvfgmqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvki
wdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidti
ktnpddcriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfnia
syalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkveki
ddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >6qyqC (C:)
prpphgelqylgqiqhilrcgvrkdtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyr
dmesdysgqgvdqlqrvidtiktnpddcriimcawnprdlplmalppchalcqfyvvnse
lscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplki
qlqreprpfpklrilrkvekiddfkaedfqiegynphptikmema

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6qyqD (D:)
mrgshhhhhhgsmpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkd
drtgtgtlsvfgmqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvki
wdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidti
ktnpddcriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfnia
syalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkveki
ddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >6qyqD (D:)
eprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwk
gvleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhf
gaeyrdmesdysgqgvdqlqrvidtiktnpddcriimcawnprdlplmalppchalcqfy
vvnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhi
eplkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmema