PDB entry 6piy
View 6piy on RCSB PDB site
Description: Crystal structure of HCV NS3/4A D168A protease in complex with P4-2 (NR02-61)
Class: hydrolase/hydrolase inhibitor
Keywords: NS3/4a Protease, Hepatitis C virus, Drug Resistance, Protease inhibitor, HYDROLASE-HYDROLASE Inhibitor complex, HYDROLASE
Deposited on
2019-06-27, released
2020-03-04
The last revision prior to the SCOPe 2.07 freeze date was dated
2020-03-04, with a file datestamp of
2020-02-28.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: N/A
AEROSPACI score: 0.35
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: NS3/4A protease
Species: Hepacivirus C [TaxId:11103]
Database cross-references and differences (RAF-indexed):
- Uniprot A0A0B4WYC6 (22-End)
- expression tag (0-21)
- conflict (31-32)
- conflict (35-36)
- conflict (39)
- conflict (65)
- conflict (70)
- conflict (90)
- conflict (104)
- conflict (177)
- engineered mutation (186)
Domains in SCOPe 2.07: d6piya1, d6piya2 - Heterogens: OMS, ZN, EDO, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6piyA (A:)
hmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivstatq
tflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctcgs
sdlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifraavstr
gvakavafipveslettmrsp
Sequence, based on observed residues (ATOM records): (download)
>6piyA (A:)
hmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivstatq
tflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctcgs
sdlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifraavstr
gvakavafipveslettm