PDB entry 6oc1

View 6oc1 on RCSB PDB site
Description: Crystal structure of human DHODH with TAK-632
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: DHODH, Inhibitor, TAK-632, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2019-03-21, released 2019-11-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-11-13, with a file datestamp of 2019-11-08.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6oc1a_
  • Heterogens: ORO, FMN, PO4, 1SU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6oc1A (A:)
hmmatgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghk
frnpvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinry
gfnshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgplad
ylvvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdked
iasvvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgr
vpiigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvt
daigadhrr

    Sequence, based on observed residues (ATOM records): (download) 
    >6oc1A (A:)
tgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnp
vgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfns
hglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvv
nvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasv
vkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpii
gvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaig
adh