PDB entry 6nj7

View 6nj7 on RCSB PDB site
Description: 11-beta dehydrogenase isozyme 1 in complex with colletoic acid
Class: oxidoreductase
Keywords: dehydrogenase, inhibitor, complex, glucocorticoid regulation, oxidoreductase
Deposited on 2019-01-02, released 2019-07-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-07-24, with a file datestamp of 2019-07-19.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD11B1, HSD11, HSD11L, SDR26C1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28845
      • engineered mutation (268)
    Domains in SCOPe 2.07: d6nj7a_
  • Chain 'B':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD11B1, HSD11, HSD11L, SDR26C1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28845
      • engineered mutation (268)
    Domains in SCOPe 2.07: d6nj7b_
  • Chain 'C':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD11B1, HSD11, HSD11L, SDR26C1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28845
      • engineered mutation (268)
    Domains in SCOPe 2.07: d6nj7c_
  • Chain 'D':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD11B1, HSD11, HSD11L, SDR26C1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28845
      • engineered mutation (268)
    Domains in SCOPe 2.07: d6nj7d_
  • Heterogens: NAP, 7H6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6nj7A (A:)
mkhqhqhqhqhqhqqplqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvv
tarsketlqkvvshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitn
tslnlfhddihhvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaay
saskfaldgffssirkeysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecal
eiikggalrqeevyydsslwttllirnpsrkileflystsynmdrfink

    Sequence, based on observed residues (ATOM records): (download) 
    >6nj7A (A:)
gkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaasahyiagtm
edmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnflsyvvltva
alpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsrvnvsitlc
vlglidtetamkahmqaapkeecaleiikggalrqeevyydsslwttllirnpsrkilef
lys

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6nj7B (B:)
mkhqhqhqhqhqhqqplqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvv
tarsketlqkvvshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitn
tslnlfhddihhvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaay
saskfaldgffssirkeysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecal
eiikggalrqeevyydsslwttllirnpsrkileflystsynmdrfink

    Sequence, based on observed residues (ATOM records): (download) 
    >6nj7B (B:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflyst

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6nj7C (C:)
mkhqhqhqhqhqhqqplqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvv
tarsketlqkvvshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitn
tslnlfhddihhvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaay
saskfaldgffssirkeysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecal
eiikggalrqeevyydsslwttllirnpsrkileflystsynmdrfink

    Sequence, based on observed residues (ATOM records): (download) 
    >6nj7C (C:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavmqaapkeecaleiikggalrqeevyydsslwttllirn
psrkilefly

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6nj7D (D:)
mkhqhqhqhqhqhqqplqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvv
tarsketlqkvvshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitn
tslnlfhddihhvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaay
saskfaldgffssirkeysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecal
eiikggalrqeevyydsslwttllirnpsrkileflystsynmdrfink

    Sequence, based on observed residues (ATOM records): (download) 
    >6nj7D (D:)
rpemlqgkkvivtgaskgigremayhlakmgahvvvtartlqkvvshclelgaasahyia
gtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnflsyvvl
tvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsrvnvsi
tlcvlglidtetamkavhmqaapkeecaleiikggalrqeevyydsslwttllirnpsrk
ileflyst