PDB entry 6h3k

View 6h3k on RCSB PDB site
Description: Introduction of a methyl group curbs metabolism of pyrido[3,4-d]pyrimidine MPS1 inhibitors and enables the discovery of the Phase 1 clinical candidate BOS172722.
Class: transferase
Keywords: Kinase, Spindle assembly checkpoint, mitosis, transferase
Deposited on 2018-07-19, released 2018-09-19
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-09-19, with a file datestamp of 2018-09-14.
Experiment type: XRAY
Resolution: 2.48 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase TTK
    Species: Homo sapiens [TaxId:9606]
    Gene: TTK, MPS1, MPS1L1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P33981 (3-278)
      • expression tag (0-2)
    Domains in SCOPe 2.07: d6h3ka1, d6h3ka2
  • Heterogens: FMW, 7PE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6h3kA (A:)
qsmsvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayl
nklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleav
htihqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgtvnymppeai
kdmsssrengkskskispksdvwslgcilyymtygktpfqqiinqisklhaiidpnheie
fpdipekdlqdvlkcclkrdpkqrisipellahpyvqiq

    Sequence, based on observed residues (ATOM records): (download) 
    >6h3kA (A:)
qsmsvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayl
nklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleav
htihqhgivhsdlkpanflivdgmlklidfgianqmqptvnymppeaikdmskispksdv
wslgcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpk
qrisipellahpyvqiq