PDB entry 6dua

View 6dua on RCSB PDB site
Description: Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD6309-bound form
Class: lyase/lyase inhibitor
Keywords: PLP, heterotetramer, amino acid biosynthesis, substrate channeling, allostery, Structural Genomics, Center for Structural Genomics of Infectious Diseases, CSGID, LYASE-LYASE INHIBITOR complex
Deposited on 2018-06-20, released 2018-07-04
Made obsolete by 6ub9 on 2019-10-30

The last revision prior to the SCOPe 2.07 freeze date was dated 2018-07-04, with a file datestamp of 2018-06-29.
Experiment type: XRAY
Resolution: 2.78 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: tryptophan synthase alpha chain
  Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
  Gene: trpA, Rv1613, MTCY01B2.05
  Database cross-references and differences (RAF-indexed):
  • Uniprot P9WFY1
  Domains in SCOPe 2.07: d6duaa_
• Chain 'B':
  Compound: tryptophan synthase beta chain
  Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
  Gene: trpB, Rv1612, MTCY01B2.04
  Database cross-references and differences (RAF-indexed):
  • Uniprot P9WFX9
• Chain 'C':
  Compound: tryptophan synthase alpha chain
  Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
  Gene: trpA, Rv1613, MTCY01B2.05
  Database cross-references and differences (RAF-indexed):
  • Uniprot P9WFY1
• Chain 'D':
  Compound: tryptophan synthase beta chain
  Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
  Gene: trpB, Rv1612, MTCY01B2.04
  Database cross-references and differences (RAF-indexed):
  • Uniprot P9WFX9
• Chain 'E':
  Compound: tryptophan synthase alpha chain
  Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
  Gene: trpA, Rv1613, MTCY01B2.05
  Database cross-references and differences (RAF-indexed):
  • Uniprot P9WFY1
• Chain 'F':
  Compound: tryptophan synthase beta chain
  Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
  Gene: trpB, Rv1612, MTCY01B2.04
  Database cross-references and differences (RAF-indexed):
  • Uniprot P9WFX9
• Chain 'G':
  Compound: tryptophan synthase alpha chain
  Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
  Gene: trpA, Rv1613, MTCY01B2.05
  Database cross-references and differences (RAF-indexed):
  • Uniprot P9WFY1
  Domains in SCOPe 2.07: d6duag_
• Chain 'H':
  Compound: tryptophan synthase beta chain
  Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
  Gene: trpB, Rv1612, MTCY01B2.04
  Database cross-references and differences (RAF-indexed):
  • Uniprot P9WFX9
• Heterogens: FMT, MLA, P1T, H9V, CS, ACT, PGE, EDO, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >6duaA (A:)
  mvaveqseasrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgv
  pysdpgmdgptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdaf
  ardlaaagglglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfv
  yaastmgvtgardavsqaapelvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgs
  alvtalteglprlraltgelaagvrlgmsahhhhhh
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6duaA (A:)
  easrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgvpysdpgm
  dgptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdafardlaaa
  gglglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfvyaassqa
  apelvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgsalvtalteglprlraltg
  elaagvrlg
  

  
  
• Chain 'B':
  No sequence available.
  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  No sequence available.
  
  
• Chain 'G':
  Sequence, based on SEQRES records: (download)
  

  >6duaG (G:)
  mvaveqseasrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgv
  pysdpgmdgptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdaf
  ardlaaagglglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfv
  yaastmgvtgardavsqaapelvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgs
  alvtalteglprlraltgelaagvrlgmsahhhhhh
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6duaG (G:)
  asrlgpvfdscrannraaligylptgypdvpasvaamtalvesgcdiievgvpysdpgmd
  gptiarateaalrggvrvrdtlaaveaisiaggravvmtywnpvlrygvdafardlaaag
  glglitpdlipdeaqqwlaaseehrldriflvapsstperlaatveasrgfvyaassqaa
  pelvgrvkavsdipvgvglgvrsraqaaqiaqyadgvivgsalvtalteglprlraltge
  laagvrlg
  

  
  
• Chain 'H':
  No sequence available.