PDB entry 6diq

View 6diq on RCSB PDB site
Description: Crystal structure of HCV NS3/4A protease in complex with P4-P5-1 (WK-23)
Class: HYDROLASE/HYDROLASE Inhibitor
Keywords: NS3/4a Protease, Hepatitis C virus, Drug Resistance, Protease inhibitor, HYDROLASE-HYDROLASE Inhibitor complex, HYDROLASE
Deposited on 2018-05-23, released 2019-07-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-07-31, with a file datestamp of 2019-07-26.
Experiment type: XRAY
Resolution: 1.58 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NS3 protease
    Species: Hepacivirus C [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0B4WYC6 (22-End)
      • expression tag (1-21)
      • conflict (31-32)
      • conflict (35-36)
      • conflict (39)
      • conflict (65)
      • conflict (70)
      • conflict (90)
      • conflict (104)
      • conflict (177)
    Domains in SCOPe 2.07: d6diqa1, d6diqa2
  • Heterogens: GK7, SO4, ZN, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6diqA (A:)
hmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivstatq
tflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctcgs
sdlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifraavstr
gvakavdfipveslettmr

    Sequence, based on observed residues (ATOM records): (download) 
    >6diqA (A:)
masmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivstatqt
flatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctcgss
dlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifraavstrg
vakavdfipveslettm