PDB entry 6chw
View 6chw on RCSB PDB site
Description: Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942.
Class: nuclear protein/antagonist
Keywords: Nuclear hormone receptor, covalent antagonist, activating mutation, breast cancer, NUCLEAR PROTEIN, nuclear protein-antagonist complex
Deposited on
2018-02-23, released
2018-03-21
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-02-26, with a file datestamp of
2020-02-21.
Experiment type: XRAY
Resolution: 1.89 Å
R-factor: N/A
AEROSPACI score: 0.35
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Estrogen receptor
Species: Homo sapiens [TaxId:9606]
Gene: ESR1, ESR, NR3A1
Database cross-references and differences (RAF-indexed):
- Uniprot P03372 (0-245)
- engineered mutation (75)
- engineered mutation (111)
- engineered mutation (231)
Domains in SCOPe 2.08: d6chwa_ - Heterogens: F3D, EDO, DMS, HOH