PDB entry 6c89

View 6c89 on RCSB PDB site
Description: NDM-1 Beta-Lactamase Exhibits Differential Active Site Sequence Requirements for the Hydrolysis of Penicillin versus Carbapenem Antibiotics
Class: antimicrobial protein
Keywords: NDM-1; beta-lactamase; deep sequencing; antibiotic resistance; beta-lactams, ANTIMICROBIAL PROTEIN
Deposited on 2018-01-24, released 2018-12-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-12-12, with a file datestamp of 2018-12-07.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-lactamase
    Species: Escherichia coli [TaxId:562]
    Gene: blaNDM-1, bla NDM-1, AM434_27040, APU18_05360, AZ95_0035, BET08_16280, BVL39_26630, CA268_28970, ECS01_0033, MS6198_A142, NDM1Dok01_N0175, pNDM102337_147, pNDM10505_149
    Database cross-references and differences (RAF-indexed):
    • Uniprot E5KIY2 (0-230)
      • engineered mutation (171)
      • engineered mutation (179-180)
    Domains in SCOPe 2.07: d6c89a_
  • Chain 'B':
    Compound: Beta-lactamase
    Species: Escherichia coli [TaxId:562]
    Gene: blaNDM-1, bla NDM-1, AM434_27040, APU18_05360, AZ95_0035, BET08_16280, BVL39_26630, CA268_28970, ECS01_0033, MS6198_A142, NDM1Dok01_N0175, pNDM102337_147, pNDM10505_149
    Database cross-references and differences (RAF-indexed):
    • Uniprot E5KIY2 (Start-230)
      • engineered mutation (171)
      • engineered mutation (179-180)
    Domains in SCOPe 2.07: d6c89b_
  • Chain 'C':
    Compound: Beta-lactamase
    Species: Escherichia coli [TaxId:562]
    Gene: blaNDM-1, bla NDM-1, AM434_27040, APU18_05360, AZ95_0035, BET08_16280, BVL39_26630, CA268_28970, ECS01_0033, MS6198_A142, NDM1Dok01_N0175, pNDM102337_147, pNDM10505_149
    Database cross-references and differences (RAF-indexed):
    • Uniprot E5KIY2 (Start-230)
      • engineered mutation (171)
      • engineered mutation (179-180)
    Domains in SCOPe 2.07: d6c89c_
  • Chain 'D':
    Compound: Beta-lactamase
    Species: Escherichia coli [TaxId:562]
    Gene: blaNDM-1, bla NDM-1, AM434_27040, APU18_05360, AZ95_0035, BET08_16280, BVL39_26630, CA268_28970, ECS01_0033, MS6198_A142, NDM1Dok01_N0175, pNDM102337_147, pNDM10505_149
    Database cross-references and differences (RAF-indexed):
    • Uniprot E5KIY2 (0-230)
      • engineered mutation (171)
      • engineered mutation (179-180)
    Domains in SCOPe 2.07: d6c89d_
  • Heterogens: ZN, EDO, NA, CL, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6c89A (A:)
etgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtddqta
qilnwikqeinlpvalavvthahqdkmggmdalhaagiatyanalsnqlapqegmvaaqh
sltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclirdskaksla
qlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6c89B (B:)
etgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtddqta
qilnwikqeinlpvalavvthahqdkmggmdalhaagiatyanalsnqlapqegmvaaqh
sltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclirdskaksla
qlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

    Sequence, based on observed residues (ATOM records): (download) 
    >6c89B (B:)
gdqrfgdlvfrqlapnvwqhtsyldmpgavasnglivrdggrvlvvdtawtddqtaqiln
wikqeinlpvalavvthahqdkmggmdalhaagiatyanalsnqlapqegmvaaqhsltf
aangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclirdskakslaqlgd
adtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6c89C (C:)
etgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtddqta
qilnwikqeinlpvalavvthahqdkmggmdalhaagiatyanalsnqlapqegmvaaqh
sltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclirdskaksla
qlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

    Sequence, based on observed residues (ATOM records): (download) 
    >6c89C (C:)
dqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtddqtaqil
nwikqeinlpvalavvthahqdkmggmdalhaagiatyanalsnqlapqegmvaaqhslt
faangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclirdskakslaqlg
dadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6c89D (D:)
etgdqrfgdlvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlvvdtawtddqta
qilnwikqeinlpvalavvthahqdkmggmdalhaagiatyanalsnqlapqegmvaaqh
sltfaangwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclirdskaksla
qlgdadtehyaasarafgaafpkasmivmshsapdsraaithtarmadklr