PDB entry 6b1u

View 6b1u on RCSB PDB site
Description: Structure of full-length human AMPK (a2b1g1) in complex with a small molecule activator SC4
Class: transferase
Keywords: Phosphorylated, Active, Heterotrimer, Kinase., TRANSFERASE
Deposited on 2017-09-19, released 2018-04-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-04-25, with a file datestamp of 2018-04-20.
Experiment type: XRAY
Resolution: 2.77 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5'-AMP-activated protein kinase catalytic subunit alpha-2
    Species: Homo sapiens [TaxId:9606]
    Gene: PRKAA2, AMPK, AMPK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P54646
      • conflict (283)
  • Chain 'B':
    Compound: 5'-AMP-activated protein kinase subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PRKAB1, AMPK
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: 5'-AMP-activated protein kinase catalytic subunit alpha-2
    Species: Homo sapiens [TaxId:9606]
    Gene: PRKAA2, AMPK, AMPK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P54646 (Start-564)
      • conflict (283)
  • Chain 'D':
    Compound: 5'-AMP-activated protein kinase subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PRKAB1, AMPK
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: 5'-amp-activated protein kinase subunit gamma-1
    Species: Homo sapiens [TaxId:9606]
    Gene: Prkag1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6b1ue1, d6b1ue2
  • Chain 'F':
    Compound: 5'-amp-activated protein kinase subunit gamma-1
    Species: Homo sapiens [TaxId:9606]
    Gene: Prkag1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6b1uf1, d6b1uf2
  • Heterogens: CG7, STU, IMD, AMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6b1uE (E:)
madlnwetvissdsspavenehpqetpesnnsvytsfmkshrcydliptssklvvfdtsl
qvkkaffalvtngvraaplwdskkqsfvgmltitdfinilhryyksalvqiyeleehkie
twrevylqdsfkplvcispnaslfdavsslirnkihrlpvidpesgntlyilthkrilkf
lklfitefpkpefmsksleelqigtyaniamvrtttpvyvalgifvqhrvsalpvvdekg
rvvdiyskfdvinlaaektynnldvsvtkalqhrshyfegvlkcylhetletiinrlvea
evhrlvvvdendvvkgivslsdilqalvltggekkp

    Sequence, based on observed residues (ATOM records): (download) 
    >6b1uE (E:)
nsvytsfmkshrcydliptssklvvfdtslqvkkaffalvtngvraaplwdskkqsfvgm
ltitdfinilhryyksalvqiyeleehkietwrevylqsfkplvcispnaslfdavssli
rnkihrlpvidpesgntlyilthkrilkflklfitefpkpefmsksleelqigtyaniam
vrtttpvyvalgifvqhrvsalpvvdekgrvvdiyskfdvinlaaektynnldvsvtkal
qhrshyfegvlkcylhetletiinrlveaevhrlvvvdendvvkgivslsdilqalvlt

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6b1uF (F:)
madlnwetvissdsspavenehpqetpesnnsvytsfmkshrcydliptssklvvfdtsl
qvkkaffalvtngvraaplwdskkqsfvgmltitdfinilhryyksalvqiyeleehkie
twrevylqdsfkplvcispnaslfdavsslirnkihrlpvidpesgntlyilthkrilkf
lklfitefpkpefmsksleelqigtyaniamvrtttpvyvalgifvqhrvsalpvvdekg
rvvdiyskfdvinlaaektynnldvsvtkalqhrshyfegvlkcylhetletiinrlvea
evhrlvvvdendvvkgivslsdilqalvltggekkp

    Sequence, based on observed residues (ATOM records): (download) 
    >6b1uF (F:)
nnsvytsfmkshrcydliptssklvvfdtslqvkkaffalvtngvraaplwdskkqsfvg
mltitdfinilhryyksalvqiyeleehkietwrevylqsfkplvcispnaslfdavssl
irnkihrlpvidpesgntlyilthkrilkflklfitefpkpefmsksleelqigtyania
mvrtttpvyvalgifvqhrvsalpvvdekgrvvdiyskfdvinlaaektynnldvsvtka
lqhrshyfegvlkcylhetletiinrlveaevhrlvvvdendvvkgivslsdilqalvl