PDB entry 6arh

View 6arh on RCSB PDB site
Description: Crystal structure of Human NAL at a resolution of 1.6 Angstrom
Class: lyase
Keywords: Lyase, sugar metabolism, sialic acid, tetramer
Deposited on 2017-08-22, released 2018-08-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-08-22, with a file datestamp of 2018-08-17.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: n-acetylneuraminate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: NPL, C1orf13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6arha_
  • Chain 'B':
    Compound: n-acetylneuraminate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: NPL, C1orf13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6arhb_
  • Chain 'C':
    Compound: n-acetylneuraminate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: NPL, C1orf13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6arhc_
  • Chain 'D':
    Compound: n-acetylneuraminate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: NPL, C1orf13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6arhd_
  • Heterogens: ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6arhA (A:)
mghhhhhhgenlyfqggsmafpkkklqglvaatitpmtengeinfsvigqyvdylvkeqg
vknifvngttgeglslsvserrqvaeewvtkgkdkldqviihvgalslkesqelaqhaae
igadgiaviapfflkpwtkdilinflkevaaaapalpfyyyhipaltgvkiraeelldgi
ldkiptfqglkfsdtdlldfgqcvdqnrqqqfaflfgvdeqllsalvmgatgavgstyny
lgkktnqmleafeqkdfslalnyqfciqrfinfvvklgfgvsqtkaimtlvsgipmgppr
lplqkasreftdsaeaklksldflsftdlkdgnleags

    Sequence, based on observed residues (ATOM records): (download) 
    >6arhA (A:)
klqglvaatitpmtengeinfsvigqyvdylvkeqgvknifvngttgeglslsvserrqv
aeewvtkgkdkldqviihvgalslkesqelaqhaaeigadgiaviapfflkpwtkdilin
flkevaaaapalpfyyyhipaltgvkiraeelldgildkiptfqglkfsdtdlldfgqcv
dqnrqqqfaflfgvdeqllsalvmgatgavgstynylgkktnqmleafeqkdfslalnyq
fciqrfinfvvklgfgvsqtkaimtlvsgipmgpprlplqkasreftdsaeaklksldfl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6arhB (B:)
mghhhhhhgenlyfqggsmafpkkklqglvaatitpmtengeinfsvigqyvdylvkeqg
vknifvngttgeglslsvserrqvaeewvtkgkdkldqviihvgalslkesqelaqhaae
igadgiaviapfflkpwtkdilinflkevaaaapalpfyyyhipaltgvkiraeelldgi
ldkiptfqglkfsdtdlldfgqcvdqnrqqqfaflfgvdeqllsalvmgatgavgstyny
lgkktnqmleafeqkdfslalnyqfciqrfinfvvklgfgvsqtkaimtlvsgipmgppr
lplqkasreftdsaeaklksldflsftdlkdgnleags

    Sequence, based on observed residues (ATOM records): (download) 
    >6arhB (B:)
kklqglvaatitpmtengeinfsvigqyvdylvkeqgvknifvngttgeglslsvserrq
vaeewvtkgkdkldqviihvgalslkesqelaqhaaeigadgiaviapfflkpwtkdili
nflkevaaaapalpfyyyhipaltgvkiraeelldgildkiptfqglkfsdtdlldfgqc
vdqnrqqqfaflfgvdeqllsalvmgatgavgstynylgkktnqmleafeqkdfslalny
qfciqrfinfvvklgfgvsqtkaimtlvsgipmgpprlplqkasreftdsaeaklksldf
lsf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6arhC (C:)
mghhhhhhgenlyfqggsmafpkkklqglvaatitpmtengeinfsvigqyvdylvkeqg
vknifvngttgeglslsvserrqvaeewvtkgkdkldqviihvgalslkesqelaqhaae
igadgiaviapfflkpwtkdilinflkevaaaapalpfyyyhipaltgvkiraeelldgi
ldkiptfqglkfsdtdlldfgqcvdqnrqqqfaflfgvdeqllsalvmgatgavgstyny
lgkktnqmleafeqkdfslalnyqfciqrfinfvvklgfgvsqtkaimtlvsgipmgppr
lplqkasreftdsaeaklksldflsftdlkdgnleags

    Sequence, based on observed residues (ATOM records): (download) 
    >6arhC (C:)
klqglvaatitpmtengeinfsvigqyvdylvkeqgvknifvngttgeglslsvserrqv
aeewvtkgkdkldqviihvgalslkesqelaqhaaeigadgiaviapfflkpwtkdilin
flkevaaaapalpfyyyhipaltgvkiraeelldgildkiptfqglkfsdtdlldfgqcv
dqnrqqqfaflfgvdeqllsalvmgatgavgstynylgkktnqmleafeqkdfslalnyq
fciqrfinfvvklgfgvsqtkaimtlvsgipmgpprlplqkasreftdsaeaklksldfl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6arhD (D:)
mghhhhhhgenlyfqggsmafpkkklqglvaatitpmtengeinfsvigqyvdylvkeqg
vknifvngttgeglslsvserrqvaeewvtkgkdkldqviihvgalslkesqelaqhaae
igadgiaviapfflkpwtkdilinflkevaaaapalpfyyyhipaltgvkiraeelldgi
ldkiptfqglkfsdtdlldfgqcvdqnrqqqfaflfgvdeqllsalvmgatgavgstyny
lgkktnqmleafeqkdfslalnyqfciqrfinfvvklgfgvsqtkaimtlvsgipmgppr
lplqkasreftdsaeaklksldflsftdlkdgnleags

    Sequence, based on observed residues (ATOM records): (download) 
    >6arhD (D:)
kklqglvaatitpmtengeinfsvigqyvdylvkeqgvknifvngttgeglslsvserrq
vaeewvtkgkdkldqviihvgalslkesqelaqhaaeigadgiaviapfflkpwtkdili
nflkevaaaapalpfyyyhipaltgvkiraeelldgildkiptfqglkfsdtdlldfgqc
vdqnrqqqfaflfgvdeqllsalvmgatgavgstynylgkktnqmleafeqkdfslalny
qfciqrfinfvvklgfgvsqtkaimtlvsgipmgpprlplqkasreftdsaeaklksldf
l