PDB entry 5wkp

View 5wkp on RCSB PDB site
Description: Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A
Class: transferase
Keywords: Human mitochondrial cysteine desulfurse LYR Motif containing protein 4 Iron-Sulfur Cluster Scaffold Protein ISCU1 Acyl Carrier Protein 1 (E.coli), TRANSFERASE
Deposited on 2017-07-25, released 2017-11-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 3.15 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cysteine desulfurase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: NFS1, NIFS, HUSSY-08
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y697 (4-End)
      • expression tag (3)
    Domains in SCOPe 2.07: d5wkpa1, d5wkpa2
  • Chain 'B':
    Compound: LYR motif-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: LYRM4, C6orf149, ISD11, CGI-203
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Acyl carrier protein
    Species: Escherichia coli [TaxId:562]
    Gene: acpP, ECS88_1108
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5wkpc_
  • Chain 'D':
    Compound: Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ISCU, NIFUN
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H1K1
      • engineered mutation (114)
    Domains in SCOPe 2.07: d5wkpd_
  • Chain 'E':
    Compound: Cysteine desulfurase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: NFS1, NIFS, HUSSY-08
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y697 (4-End)
      • expression tag (2-3)
    Domains in SCOPe 2.07: d5wkpe1, d5wkpe2
  • Chain 'F':
    Compound: LYR motif-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: LYRM4, C6orf149, ISD11, CGI-203
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Acyl carrier protein
    Species: Escherichia coli [TaxId:562]
    Gene: acpP, ECS88_1108
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5wkpg_
  • Chain 'H':
    Compound: Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ISCU, NIFUN
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H1K1
      • engineered mutation (114)
    Domains in SCOPe 2.07: d5wkph_
  • Heterogens: PLP, 8Q1

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5wkpA (A:)
mgsslrplymdvqattpldprvldamlpylinyygnphsrthaygweseaamerarqqva
sligadpreiiftsgatesnniaikgvarfyrsrkkhlittqtehkcvldscrsleaegf
qvtylpvqksgiidlkeleaaiqpdtslvsvmtvnneigvkqpiaeigricssrkvyfht
daaqavgkipldvndmkidlmsisghkiygpkgvgaiyirrrprvrvealqsgggqergm
rsgtvptplvvglgaacevaqqemeydhkrisklserliqnimkslpdvvmngdpkhhyp
gcinlsfayvegesllmalkdvalssgsactsaslepsyvlraigtdedlahssirfgig
rftteeevdytvekciqhvkrlremsplwemvqdgidlksikwtqh

    Sequence, based on observed residues (ATOM records): (download) 
    >5wkpA (A:)
slrplymdvqattpldprvldamlpylinyygnphsrthaygweseaamerarqqvasli
gadpreiiftsgatesnniaikgvarfyrsrkkhlittqtehkcvldscrsleaegfqvt
ylpvqksgiidlkeleaaiqpdtslvsvmtvnneigvkqpiaeigricssrkvyfhtdaa
qavgkipldvndmkidlmsisghkiygpkgvgaiyirrrprvrvealqsgggqergmrsg
tvptplvvglgaacevaqqemeydhkrisklserliqnimkslpdvvmngdpkhhypgci
nlsfayvegesllmalkdvalssgsalepsyvlraigtdedlahssirfgigrftteeev
dytvekciqhvkrlremsplwemvqdgidlksikwt

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5wkpC (C:)
stieervkkiigeqlgvkqeevtnnasfvedlgadsldtvelvmaleeefdteipdeeae
kittvqaaidyinghqa

    Sequence, based on observed residues (ATOM records): (download) 
    >5wkpC (C:)
eervkkiigeqlgvkqeevtnnasfvedlgadsldtvelvmaleeefdteipdeeaekit
tvqaaidyingh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5wkpD (D:)
mvlidmsvdlstqvvdhyenprnvgsldktsknvgtglvgapacgdvmklqiqvdekgki
vdarfktfgcgsaiassslatewvkgktveealtikntdiakelclppvklhcsilaeda
ikaaladyklkqepkkgeaekklehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5wkpD (D:)
vdhyenprnvgsldktsknvgtglvgapacgdvmklqiqvdekgkivdarfktfgcgsai
assslatewvkgktveealtikntdiakelclppvklhcsilaedaikaaladyklkq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5wkpE (E:)
mgsslrplymdvqattpldprvldamlpylinyygnphsrthaygweseaamerarqqva
sligadpreiiftsgatesnniaikgvarfyrsrkkhlittqtehkcvldscrsleaegf
qvtylpvqksgiidlkeleaaiqpdtslvsvmtvnneigvkqpiaeigricssrkvyfht
daaqavgkipldvndmkidlmsisghkiygpkgvgaiyirrrprvrvealqsgggqergm
rsgtvptplvvglgaacevaqqemeydhkrisklserliqnimkslpdvvmngdpkhhyp
gcinlsfayvegesllmalkdvalssgsactsaslepsyvlraigtdedlahssirfgig
rftteeevdytvekciqhvkrlremsplwemvqdgidlksikwtqh

    Sequence, based on observed residues (ATOM records): (download) 
    >5wkpE (E:)
sslrplymdvqattpldprvldamlpylinyygnphsrthaygweseaamerarqqvasl
igadpreiiftsgatesnniaikgvarfyrsrkkhlittqtehkcvldscrsleaegfqv
tylpvqksgiidlkeleaaiqpdtslvsvmtvnneigvkqpiaeigricssrkvyfhtda
aqavgkipldvndmkidlmsisghkiygpkgvgaiyirrrprvrvealqsgggqergmrs
gtvptplvvglgaacevaqqemeydhkrisklserliqnimkslpdvvmngdpkhhypgc
inlsfayvegesllmalkdvalssgsslepsyvlraigtdedlahssirfgigrftteee
vdytvekciqhvkrlremsplwemvqdgidlksikwtq

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5wkpG (G:)
stieervkkiigeqlgvkqeevtnnasfvedlgadsldtvelvmaleeefdteipdeeae
kittvqaaidyinghqa

    Sequence, based on observed residues (ATOM records): (download) 
    >5wkpG (G:)
ieervkkiigeqlgvkqeevtnnasfvedlgadsldtvelvmaleeefdteipdeeaeki
ttvqaaidyin

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5wkpH (H:)
mvlidmsvdlstqvvdhyenprnvgsldktsknvgtglvgapacgdvmklqiqvdekgki
vdarfktfgcgsaiassslatewvkgktveealtikntdiakelclppvklhcsilaeda
ikaaladyklkqepkkgeaekklehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5wkpH (H:)
lstqvvdhyenprnvgsldktsknvgtglvgapacgdvmklqiqvdekgkivdarfktfg
cgsaiassslatewvkgktveealtikntdiakelclppvklhcsilaedaikaaladyk
lkqepk