PDB entry 5uav

View 5uav on RCSB PDB site
Description: Structure of human PYCR-1 complexed with NADPH and L-tetrahydrofuroic acid
Class: oxidoreductase
Keywords: amino-acid biosynthesis, oxidoreductase, proline biosynthesis
Deposited on 2016-12-20, released 2017-03-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (18-21)
    Domains in SCOPe 2.07: d5uava1, d5uava2, d5uava3
  • Chain 'B':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (16-21)
    Domains in SCOPe 2.07: d5uavb1, d5uavb2, d5uavb3
  • Chain 'C':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (18-21)
    Domains in SCOPe 2.07: d5uavc1, d5uavc2, d5uavc3
  • Chain 'D':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (16-21)
    Domains in SCOPe 2.07: d5uavd1, d5uavd2, d5uavd3
  • Chain 'E':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (21)
    Domains in SCOPe 2.07: d5uave1, d5uave2, d5uave3
  • Heterogens: NDP, TFB, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5uavA (A:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uavA (A:)
yfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphn
ketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpapr
vircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgs
gpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspgg
atihalhvlesggfrsllinaveascirtrelqsmadq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5uavB (B:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uavB (B:)
nlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltp
hnketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpa
prvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtgls
gsgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvssp
ggatihalhvlesggfrsllinaveascirtrelqsmad

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5uavC (C:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uavC (C:)
yfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphn
ketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpapr
vircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgs
gpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspgg
atihalhvlesggfrsllinaveascirtrelqsmad

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5uavD (D:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uavD (D:)
nlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltp
hnketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpa
prvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtgls
gsgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvssp
ggatihalhvlesggfrsllinaveascirtrelqsmad

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5uavE (E:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uavE (E:)
smsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnket
vqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvir
cmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpa
yaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggati
halhvlesggfrsllinaveascirtrelqsmadq