SCOPe 2.08: Structural Classification of Proteins — extended

PDB entry 5u2b

View 5u2b on RCSB PDB site
Description: Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the phenylamino-substituted estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(phenylamino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol, without a coactivator peptide
Class: transcription
Keywords: protein ligand complex, TRANSCRIPTION
Deposited on 2016-11-30, released 2017-04-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.22 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Estrogen receptor
Species: Homo sapiens [TaxId:9606]
Gene: ESR1, ESR, NR3A1
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
  - engineered mutation (239)
Domains in SCOPe 2.08: d5u2ba_
Chain 'B':
Compound: Estrogen receptor
Species: Homo sapiens [TaxId:9606]
Gene: ESR1, ESR, NR3A1
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
  - engineered mutation (239)
Domains in SCOPe 2.08: d5u2bb_
Chain 'C':
Compound: Estrogen receptor
Species: Homo sapiens [TaxId:9606]
Gene: ESR1, ESR, NR3A1
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
  - engineered mutation (239)
Domains in SCOPe 2.08: d5u2bc_
Chain 'D':
Compound: Estrogen receptor
Species: Homo sapiens [TaxId:9606]
Gene: ESR1, ESR, NR3A1
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
  - engineered mutation (239)
Domains in SCOPe 2.08: d5u2bd_
Chain 'E':
Compound: Estrogen receptor
Species: Homo sapiens [TaxId:9606]
Gene: ESR1, ESR, NR3A1
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
  - engineered mutation (239)
Domains in SCOPe 2.08: d5u2be_
Chain 'F':
Compound: Estrogen receptor
Species: Homo sapiens [TaxId:9606]
Gene: ESR1, ESR, NR3A1
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
  - engineered mutation (239)
Domains in SCOPe 2.08: d5u2bf_
Heterogens: 6WV, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>5u2bA (A:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpls
dlllemldahrlhapts

Sequence, based on observed residues (ATOM records): (download)

>5u2bA (A:)
krskknslalsltadqmvsalldaeppilyseydppfseasmmglltnladrelvhminw
akrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcveg
mveifdmllatssrfrmmnlqgeefvclksiillnsgvytfsstlksleekdhihrvldk
itdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkclsdlllemlda
hr

Chain 'B':
Sequence, based on SEQRES records: (download)

>5u2bB (B:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpls
dlllemldahrlhapts

Sequence, based on observed residues (ATOM records): (download)

>5u2bB (B:)
nslalsltadqmvsalldaeppilyseydptasmmglltnladrelvhminwakrvpgfv
dltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdml
latssrfrmmnlqgeefvclksiillnsgvykdhihrvldkitdtlihlmakagltlqqq
hqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahr

Chain 'C':
Sequence, based on SEQRES records: (download)

>5u2bC (C:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpls
dlllemldahrlhapts

Sequence, based on observed residues (ATOM records): (download)

>5u2bC (C:)
rskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhmin
wakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcve
gmveifdmllatssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldki
tdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcvplsdlllemld
ahrl

Chain 'D':
Sequence, based on SEQRES records: (download)

>5u2bD (D:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpls
dlllemldahrlhapts

Sequence, based on observed residues (ATOM records): (download)

>5u2bD (D:)
nslalsltadqmvsalldaeppilyseasmmglltnladrelvhminwakrvpgfvdltl
hdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllats
srfrmmnlqgeefvclksiillnsgvyeekdhihrvldkitdtlihlmakagltlqqqhq
rlaqlllilshirhmsnkgmehlysmkckvplsdlllemldahrlh

Chain 'E':
Sequence, based on SEQRES records: (download)

>5u2bE (E:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpls
dlllemldahrlhapts

Sequence, based on observed residues (ATOM records): (download)

>5u2bE (E:)
lalsltadqmvsalldaeppilyseydpseasmmglltnladrelvhminwakrvpgfvd
ltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmll
atssrfrmmnlqgeefvclksiillnsgvytfekdhihrvldkitdtlihlmakagltlq
qqhqrlaqlllilshirhmsnkgmehlyssdlllemldahr

Chain 'F':
Sequence, based on SEQRES records: (download)

>5u2bF (F:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpls
dlllemldahrlhapts

Sequence, based on observed residues (ATOM records): (download)

>5u2bF (F:)
kknslalsltadqmvsalldaeppilyssmmglltnladrelvhminwakrvpgfvdltl
hdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllats
srfrmmnlqgeefvclksiillnsgtlksleekdhihrvldkitdtlihlmakagltlqq
qhqrlaqlllilshirhmsnkgmehlysmkcklsdlllemldahr