PDB entry 5tx9

View 5tx9 on RCSB PDB site
Description: Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with ceftobiprole
Class: HYDROLASE / Antibiotic
Keywords: HYDROLASE, Antibiotic, HYDROLASE - Antibiotic complex
Deposited on 2016-11-16, released 2018-05-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-05-16, with a file datestamp of 2018-05-11.
Experiment type: XRAY
Resolution: 1.68 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Penicillin-binding protein 4
    Species: Staphylococcus aureus (strain COL) [TaxId:93062]
    Gene: pbp4, SACOL0699
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0H2WY27 (0-End)
      • engineered mutation (158)
      • engineered mutation (216)
    Domains in SCOPe 2.07: d5tx9a1, d5tx9a2
  • Chain 'B':
    Compound: Penicillin-binding protein 4
    Species: Staphylococcus aureus (strain COL) [TaxId:93062]
    Gene: pbp4, SACOL0699
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0H2WY27 (0-358)
      • engineered mutation (158)
      • engineered mutation (216)
    Domains in SCOPe 2.07: d5tx9b1, d5tx9b2
  • Heterogens: ZN, RB6, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5tx9A (A:)
tnsdvtpvqaanqygyaglsaayeptsavnvsqtgqllyqynidtkwnpasmtklmtmyl
tleavnkgqlslddtvtmtnkeyimstlpelsntklypgqvwtiadllqitvsnssnaaa
lilakkvskntsdfvdlmnnkakaigmknthfvnptgaansrlrtfaptkykdqertvtt
ardyaildlhviketpkildftkqlaptthavtyytrnfslegakmslpgtdglktgssd
tanynhtittkrgkfrinqvimgagdyknlggekqrnmmgnalmersfdqykyvkilskg
eqringkkyyvendlydvlpsdfskkdyklvvedgkvhadyprefinkdygpptvevhq

    Sequence, based on observed residues (ATOM records): (download) 
    >5tx9A (A:)
tnsdvtpvqaanqygyaglsaayeptsavnvsqtgqllyqynidtkwnpasmtklmtmyl
tleavnkgqlslddtvtmtnkeyimstlpelsntklypgqvwtiadllqitvsnssnaaa
lilakkvskntsdfvdlmnnkakaigmknthfvnptgaansrlrtfaptkykdqertvtt
ardyaildlhviketpkildftkqlaptthavtyytrnfslegakmslpgtdglktgssd
tanynhtittkrgkfrinqvimgagdyknlggekqrnmmgnalmersfdqykyvkilskg
eqringkkyyvendlydvlpsdfskkdyklvvedgkvhadyprefinkdygpptvevh

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5tx9B (B:)
tnsdvtpvqaanqygyaglsaayeptsavnvsqtgqllyqynidtkwnpasmtklmtmyl
tleavnkgqlslddtvtmtnkeyimstlpelsntklypgqvwtiadllqitvsnssnaaa
lilakkvskntsdfvdlmnnkakaigmknthfvnptgaansrlrtfaptkykdqertvtt
ardyaildlhviketpkildftkqlaptthavtyytrnfslegakmslpgtdglktgssd
tanynhtittkrgkfrinqvimgagdyknlggekqrnmmgnalmersfdqykyvkilskg
eqringkkyyvendlydvlpsdfskkdyklvvedgkvhadyprefinkdygpptvevhq