PDB entry 5t6g

View 5t6g on RCSB PDB site
Description: 2.45 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7m (hexagonal form)
Class: protease/protease inhibitor
Keywords: PROTEASE, NOROVIRUS, NORWALK VIRUS, ANTIVIRAL INHIBITORS, DIPEPTIDYL INHIBITOR, PROTEASE-PROTEASE INHIBITOR complex
Deposited on 2016-09-01, released 2016-11-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Genome polyprotein
    Species: Norwalk virus [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (7-End)
      • expression tag (5-6)
    Domains in SCOPe 2.07: d5t6ga1, d5t6ga2
  • Chain 'B':
    Compound: Genome polyprotein
    Species: Norwalk virus [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5t6gb_
  • Heterogens: N40, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5t6gA (A:)
mhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale

    Sequence, based on observed residues (ATOM records): (download) 
    >5t6gA (A:)
hhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqf
rfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqs
gmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5t6gB (B:)
mhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale

    Sequence, based on observed residues (ATOM records): (download) 
    >5t6gB (B:)
tlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqfrfskk
mrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsgmllt
gmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavq