PDB entry 5s79

View 5s79 on RCSB PDB site
Description: XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010910a
Class: transferase
Keywords: SGC - Diamond I04-1 fragment screening, PanDDA, XChemExplorer, TRANSFERASE
Deposited on 2020-12-11, released 2021-06-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-06-23, with a file datestamp of 2021-06-18.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04771 (Start-300)
      • engineered mutation (8)
    Domains in SCOPe 2.07: d5s79a_
  • Chain 'B':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5s79b_
  • Heterogens: LU8, EDO, DMS, SO4, PZO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5s79A (A:)
smqrtvarditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlr
henilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglah
lhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgt
krymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpnd
psfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki
d

    Sequence, based on observed residues (ATOM records): (download) 
    >5s79A (A:)
rtvarditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrhen
ilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhi
eifggkpaiahrdlksknilvkkngqcciadlglavmhsrvgtkrymapevldetiqvdc
fdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfedmrkvvcvdqqrp
nipnrwfsdptltslaklmkecwyqnpsarltalrikktltkid

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5s79B (B:)
smqrtvarditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlr
henilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglah
lhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgt
krymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpnd
psfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki
d

    Sequence, based on observed residues (ATOM records): (download) 
    >5s79B (B:)
itllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrhenilgfia
sdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhieifgkp
aiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgtkrymapevldet
iqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfedmrkvvcv
dqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki