PDB entry 5qj0
View 5qj0 on RCSB PDB site
Description: CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide
Class: TRANSFERASE/TRANSFERASE inhibitor
Keywords: RDRP STRUCTURE (FINGERS, PALM, THUMB DOMAINS), ACETYLATION, APOPTOSIS, ATP-BINDING, CAPSID PROTEIN, CELL MEMBRANE, CYTOPLASM, DISULFIDE BOND, ENDOPLASMIC RETICULUM, ENVELOPE PROTEIN, FUSION PROTEIN, GLYCOPROTEIN, HELICASE, HOST-VIRUS INTERACTION, HYDROLASE, INTERFERON ANTIVIRAL SYSTEM EVASION, LIPID DROPLET, LIPOPROTEIN, MEMBRANE, METAL- BINDING, MITOCHONDRION, MULTIFUNCTIONAL ENZYME, NUCLEOTIDE- BINDING, NUCLEOTIDYLTRANSFERASE, NUCLEUS, ONCOGENE, PALMITATE, PHOSPHOPROTEIN, PROTEASE, RIBONUCLEOPROTEIN, RNA REPLICATION, RNA-BINDING, RNA-DIRECTED RNA POLYMERASE, SECRETED, SERINE PROTEASE, SH3-BINDING, THIOL PROTEASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, TRANSMEMBRANE, UBL CONJUGATION, VIRAL NUCLEOPROTEIN, VIRION, ZINC, TRANSFERASE-TRANSFERASE inhibitor complex
Deposited on
2018-08-13, released
2018-11-21
The last revision prior to the SCOPe 2.07 freeze date was dated
2018-11-21, with a file datestamp of
2018-11-16.
Experiment type: XRAY
Resolution: 2.08 Å
R-factor: N/A
AEROSPACI score: 0.29
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: RNA-dependent RNA polymerase
Species: Hepacivirus C [TaxId:11103]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d5qj0a_ - Heterogens: J6D, SCN, 2PE, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5qj0A (A:)
msmsyswtgalitpcspeeeklpinplsnsslryhnkvycttsksasqrakkvtfdrtqv
ldahydsvlkdiklaaskvsarlltleeacqltpphsarskygfgakevrslsgravnhi
ksvwkdlledpqtpipttimaknevfcvdpakggkkparlivypdlgvrvcekmalydit
qklpqavmgasygfqyspaqrveyllkawaekkdpmgfsydtrcfdstvterdirteesi
yqacslpeeartaihslterlyvggpmfnskgqtcgyrrcrasgvlttsmgntitcyvka
laackaagivaptmlvcgddlvvisesqgteedernlrafteamtrysappgdpprpeyd
lelitscssnvsvalgprgrrryyltrdpttplaraawetvrhspinswlgniiqyapti
wvrmvlmthffsilmvqdtldqnlnfemygsvysvnpldlpaiierlhgldafsmhtysh
heltrvasalrklgapplrvwksraravraslisrggkaavcgrylfnwavktklkltpl
pearlldlsswftvgagggdifhsvsrarprsll
Sequence, based on observed residues (ATOM records): (download)
>5qj0A (A:)
smsyswtgalitpcspeeeklpinslryhnkvycttsksasqrakkvtfdrtqvldahyd
svlkdiklaaskvsarlltleeacqltpphsarskygfgakevrslsgravnhiksvwkd
lledpqtpipttimaknevfcvdggkkparlivypdlgvrvcekmalyditqklpqavmg
asygfqyspaqrveyllkawaekkdpmgfsydtrcfdstvterdirteesiyqacslpee
artaihslterlyvggpmfnskgqtcgyrrcrasgvlttsmgntitcyvkalaackaagi
vaptmlvcgddlvvisesqgteedernlrafteamtrysappgdpprpeydlelitscss
nvsvalgprgrrryyltrdpttplaraawetvrhsnswlgniiqyaptiwvrmvlmthff
silmvqdtldqnlnfemygsvysvnpldlpaiierlhgldafsmhtyshheltrvasalr
klgapplrvwksraravraslisrggkaavcgrylfnwavktklkltplpearlldlssw
ftvgagggdifhsvsrarp