PDB entry 5pzm

View 5pzm on RCSB PDB site
Description: crystal structure of the hepatitis c virus ns5b RNA-dependent RNA polymerase in complex with 3-[2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-5-yl]benzoic acid
Class: transferase
Keywords: ns5b, polymerase, hcv, fingers, palm, thumb, transferase
Deposited on 2017-02-27, released 2017-05-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-06-14, with a file datestamp of 2017-06-09.
Experiment type: XRAY
Resolution: 2.54 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus genotype 1b (isolate Con1) [TaxId:333284]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5pzma_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus genotype 1b (isolate Con1) [TaxId:333284]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5pzmb_
  • Heterogens: 23E, SO4, 8XS, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5pzmA (A:)
msmsytwtgalitpcaaeetklpinalsnsllrhhnlvyattsrsaslrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsarskfgygakdvrnlsskavnhi
rsvwkdlledtetpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqavmgssygfqyspgqrveflvnawkakkcpmgfaydtrcfdstvtendirveesi
yqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
aaacraaklqdctmlvcgddlvvicesagtqedeaslrafteamtrysappgdppkpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiiqrlhglsafslhsysp
geinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavrtklkltpi
paasqldlsswfvagysggdiyhslsrarprwfm

    Sequence, based on observed residues (ATOM records): (download) 
    >5pzmA (A:)
smsytwtgalitpcvyattsrsaslrqkkvtfdrlqvlddhyrdvlkemkakastvkakl
lsveeackltpphsarskfgygakdvrnlsskavnhirsvwkdlledtetpidttimakn
evfcvqpekggrkparlivfpdlgvrvcekmalydvvstlpqavmgssygfqyspgqrve
flvnawkakkcpmgfaydtrcfdstvtendirveesiyqccdlapearqairslterlyi
ggpltnskgqncgyrrcrasgvlttscgntltcylkaaaacraaklqdctmlvcgddlvv
icesagtqedeaslrafteamtrysappgdppkpeydlelitscssnvsvahdasgkrvy
yltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqleka
ldcqiygacysiepldlpqiiqrlhglsafslhsyspgeinrvasclrklgvpplrvwrh
rarsvrarllsqggraatcgkylfnwavrtklkltpipaasqldlsswfvagysggdiyh
slsrarprwfm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5pzmB (B:)
msmsytwtgalitpcaaeetklpinalsnsllrhhnlvyattsrsaslrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsarskfgygakdvrnlsskavnhi
rsvwkdlledtetpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqavmgssygfqyspgqrveflvnawkakkcpmgfaydtrcfdstvtendirveesi
yqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
aaacraaklqdctmlvcgddlvvicesagtqedeaslrafteamtrysappgdppkpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiiqrlhglsafslhsysp
geinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavrtklkltpi
paasqldlsswfvagysggdiyhslsrarprwfm

    Sequence, based on observed residues (ATOM records): (download) 
    >5pzmB (B:)
smsytwtgalitpcvyattsrsaslrqkkvtfdrlqvlddhyrdvlkemkakastvkakl
lsveeackltpphsarskfgygakdvrnlsskavnhirsvwkdlledtetpidttimakn
evfcvqpekggrkparlivfpdlgvrvcekmalydvvstlpqavmgssygfqyspgqrve
flvnawkakkcpmgfaydtrcfdstvtendirveesiyqccdlapearqairslterlyi
ggpltnskgqncgyrrcrasgvlttscgntltcylkaaaacraaklqdctmlvcgddlvv
icesagtqedeaslrafteamtrysappgdppkpeydlelitscssnvsvahdasgkrvy
yltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqleka
ldcqiygacysiepldlpqiiqrlhglsafslhsyspgeinrvasclrklgvpplrvwrh
rarsvrarllsqggraatcgkylfnwavrtklkltpipaasqldlsswfvagysggdiyh
slsra