PDB entry 5kye

View 5kye on RCSB PDB site
Description: Crystal structure of USP7 catalytic domain [H294E] mutant in complex with ubiquitin
Class: hydrolase
Keywords: USP7 catalytic domain, deubiquitinase, H294E mutant, ubiquitin, HYDROLASE
Deposited on 2016-07-21, released 2017-08-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-08-09, with a file datestamp of 2017-08-04.
Experiment type: XRAY
Resolution: 1.97 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ubiquitin carboxyl-terminal hydrolase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: USP7, HAUSP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q93009
      • engineered mutation (90)
    Domains in SCOPe 2.07: d5kyea_
  • Chain 'B':
    Compound: Ubiquitin carboxyl-terminal hydrolase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: USP7, HAUSP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q93009
      • engineered mutation (90)
    Domains in SCOPe 2.07: d5kyeb_
  • Chain 'C':
    Compound: Polyubiquitin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5kyec_
  • Chain 'D':
    Compound: Polyubiquitin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5kyed_
  • Heterogens: EPE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5kyeA (A:)
gshmkkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrv
fyelqhsdkpvgtkkltksfgwetldsfmqedvqelcrvlldnvenkmkgtcvegtipkl
frgkmvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydage
hglqeaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpk
dpanyilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdd
dlsvrhctnaymlvyiresklsevlqavtdhdipqqlverlqeekrieaqk

    Sequence, based on observed residues (ATOM records): (download) 
    >5kyeA (A:)
khtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfyelq
hsdkpvgtkkltksfgwetldsfmqedvqelcrvlldnvenkmkgtcvegtipklfrgkm
vsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehglqe
aekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpkdpany
ilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdddlrhc
tnaymlvyiresklsevlqavtdhdipqqlverlqeekrieaq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5kyeB (B:)
gshmkkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrv
fyelqhsdkpvgtkkltksfgwetldsfmqedvqelcrvlldnvenkmkgtcvegtipkl
frgkmvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydage
hglqeaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpk
dpanyilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdd
dlsvrhctnaymlvyiresklsevlqavtdhdipqqlverlqeekrieaqk

    Sequence, based on observed residues (ATOM records): (download) 
    >5kyeB (B:)
tgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfyelqhs
dkpvgtkkltksfgwetldsfmqedvqelcrvlldnvenkmkgtcvegtipklfrgkmvs
yiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehglqeae
kgvkfltlppvlhlqlmrfmydpdqnikindrfefpeqlpldeflqktdpkdpanyilha
vlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnyggrhctnaymlvyi
resklsevlqavtdhdipqqlverlqeekr

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5kyeC (C:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
iqkestlhlvlrlrgg

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5kyeD (D:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
iqkestlhlvlrlrgg