PDB entry 5k0f
View 5k0f on RCSB PDB site
Description: Crystal Structure of COMT in complex with 5-[5-[1-(4-methoxyphenyl)ethyl]-1H-pyrazol-3-yl]-2,4-dimethyl-1,3-thiazole
Class: transferase
Keywords: methyltransferase, neurotransmitter degradation, catechol, transferase
Deposited on
2016-05-17, released
2016-09-07
The last revision prior to the SCOPe 2.07 freeze date was dated
2017-01-18, with a file datestamp of
2017-01-13.
Experiment type: XRAY
Resolution: 1.81 Å
R-factor: N/A
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-218)
- engineered mutation (89)
- engineered mutation (93)
- engineered mutation (154)
Domains in SCOPe 2.07: d5k0fa_ - Chain 'B':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-218)
- engineered mutation (89)
- engineered mutation (93)
- engineered mutation (154)
Domains in SCOPe 2.07: d5k0fb_ - Heterogens: NHE, 6P1, NA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>5k0fA (A:)
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspsl
vlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqd
lipqlkkkydvdtldmvfldhwkdrylpdtllleecgllrkgtvlladnvivpgtpdfla
yvrgsssfecthyssyleymkvvdglekaiyqgpsspdk
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>5k0fB (B:)
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspsl
vlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqd
lipqlkkkydvdtldmvfldhwkdrylpdtllleecgllrkgtvlladnvivpgtpdfla
yvrgsssfecthyssyleymkvvdglekaiyqgpsspdk