SCOPe 2.07: Structural Classification of Proteins

PDB entry 5k09

View 5k09 on RCSB PDB site
Description: Crystal Structure of COMT in complex with a thiazole ligand
Class: transferase
Keywords: METHYLTRANSFERASE, NEUROTRANSMITTER DEGRADATION, CATECHOL, transferase
Deposited on 2016-05-17, released 2016-09-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-12-21, with a file datestamp of 2016-12-16.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-215)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
  - expression tag (216)
Domains in SCOPe 2.07: d5k09a1, d5k09a2
Chain 'B':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09b_
Chain 'C':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-215)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09c_
Chain 'D':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09d_
Chain 'E':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09e_
Chain 'F':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-215)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09f_
Chain 'G':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-215)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
  - expression tag (216)
Domains in SCOPe 2.07: d5k09g1, d5k09g2
Chain 'H':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-215)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09h_
Chain 'I':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09i_
Chain 'J':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-215)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09j_
Chain 'K':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09k_
Chain 'L':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-215)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09l_
Chain 'M':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09m_
Chain 'N':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-215)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09n_
Chain 'O':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-215)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09o_
Chain 'P':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09p_
Chain 'Q':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-215)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09q_
Chain 'R':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-215)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
  - expression tag (216)
Domains in SCOPe 2.07: d5k09r1, d5k09r2
Chain 'S':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09s_
Chain 'T':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09t_
Chain 'U':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09u_
Chain 'V':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09v_
Chain 'W':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09w_
Chain 'X':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.07: d5k09x_
Heterogens: 6PQ, K, PO4, HOH

PDB Chain Sequences:

Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)

>5k09A (A:)
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspsl
vlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqd
lipqlkkkydvdtldmvfldhwkdrylpdtllleecgllrkgtvlladnvivpgtpdfla
yvrgsssfecthyssyleymkvvdglekaiyqgpssd

Chain 'B':
Sequence, based on SEQRES records: (download)

>5k09B (B:)
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspsl
vlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqd
lipqlkkkydvdtldmvfldhwkdrylpdtllleecgllrkgtvlladnvivpgtpdfla
yvrgsssfecthyssyleymkvvdglekaiyqgpssd