PDB entry 5jyo

View 5jyo on RCSB PDB site
Description: Allosteric inhibition of Kidney Isoform of Glutaminase
Class: hydrolase
Keywords: KGA, GAC, allosteric inhibition, Warburg effect, HYDROLASE
Deposited on 2016-05-15, released 2016-08-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-08-17, with a file datestamp of 2016-08-12.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925 (20-End)
      • expression tag (17-19)
    Domains in SCOPe 2.07: d5jyoa1, d5jyoa2
  • Chain 'B':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925 (20-End)
      • expression tag (17-19)
    Domains in SCOPe 2.07: d5jyob1, d5jyob2
  • Chain 'C':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925 (20-End)
      • expression tag (17-19)
    Domains in SCOPe 2.07: d5jyoc1, d5jyoc2
  • Chain 'D':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925 (20-End)
      • expression tag (17-19)
    Domains in SCOPe 2.07: d5jyod1, d5jyod2
  • Chain 'E':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925 (20-End)
      • expression tag (17-19)
    Domains in SCOPe 2.07: d5jyoe1, d5jyoe2
  • Chain 'F':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925 (20-End)
      • expression tag (17-19)
    Domains in SCOPe 2.07: d5jyof1, d5jyof2
  • Chain 'G':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925 (20-End)
      • expression tag (17-19)
    Domains in SCOPe 2.07: d5jyog1, d5jyog2
  • Chain 'H':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925 (20-End)
      • expression tag (17-19)
    Domains in SCOPe 2.07: d5jyoh1, d5jyoh2
  • Heterogens: 63J, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5jyoA (A:)
mgsshhhhhhssglvprgsmipdfmsftshidelyesakkqsggkvadyipqlakfspdl
wgvsvctvdgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnk
lflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqs
eresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfc
pitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmc
wsppldkmgnsvkgihfchdlvslcnfhnydnl

    Sequence, based on observed residues (ATOM records): (download) 
    >5jyoA (A:)
gsmipdfmsftshidelyesakkqsggkvadyipqlakfspdlwgvsvctvdgqrhstgd
tkvpfclqscvkplkyaiavndlgteyvhryvgkepsglnklflneddkphnpmvnagai
vvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqseresgdrnfaigyylkekk
cfpegtdmvgildfyfqlcsievtcesasvmaatlanggfcpitgervlspeavrntlsl
mhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcwsppldkmgnsvkgihfch
dlvslcnfhnyd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5jyoB (B:)
mgsshhhhhhssglvprgsmipdfmsftshidelyesakkqsggkvadyipqlakfspdl
wgvsvctvdgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnk
lflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqs
eresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfc
pitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmc
wsppldkmgnsvkgihfchdlvslcnfhnydnl

    Sequence, based on observed residues (ATOM records): (download) 
    >5jyoB (B:)
gsmipdfmsftshidelyesakkqsggkvadyipqlakfspdlwgvsvctvdgqrhstgd
tkvpfclqscvkplkyaiavndlgteyvhryvgkepsgnklflneddkphnpmvnagaiv
vtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqseresgdrnfaigyylkekkc
fpegtdmvgildfyfqlcsievtcesasvmaatlanggfcpitgervlspeavrntlslm
hscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcwsppldkmgnsvkgihfchd
lvslcnfhnyd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5jyoC (C:)
mgsshhhhhhssglvprgsmipdfmsftshidelyesakkqsggkvadyipqlakfspdl
wgvsvctvdgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnk
lflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqs
eresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfc
pitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmc
wsppldkmgnsvkgihfchdlvslcnfhnydnl

    Sequence, based on observed residues (ATOM records): (download) 
    >5jyoC (C:)
gsmipdfmsftshidelyesakkqsggkvadyipqlakfspdlwgvsvctvdgqrhstgd
tkvpfclqscvkplkyaiavndlgteyvhryvgkepsglklflneddkphnpmvnagaiv
vtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqseresgdrnfaigyylkekkc
fpegtdmvgildfyfqlcsievtcesasvmaatlanggfcpitgervlspeavrntlslm
hscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcwsppldkmgnsvkgihfchd
lvslcnfhnyd

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5jyoD (D:)
mgsshhhhhhssglvprgsmipdfmsftshidelyesakkqsggkvadyipqlakfspdl
wgvsvctvdgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnk
lflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqs
eresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfc
pitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmc
wsppldkmgnsvkgihfchdlvslcnfhnydnl

    Sequence, based on observed residues (ATOM records): (download) 
    >5jyoD (D:)
gsmipdfmsftshidelyesakkqsggkvadyipqlakfspdlwgvsvctvdgqrhstgd
tkvpfclqscvkplkyaiavndlgteyvhryvgkepsgnklflneddkphnpmvnagaiv
vtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqseresgdrnfaigyylkekkc
fpegtdmvgildfyfqlcsievtcesasvmaatlanggfcpitgervlspeavrntlslm
hscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcwsppldkmgnsvkgihfchd
lvslcnfhnyd

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5jyoE (E:)
mgsshhhhhhssglvprgsmipdfmsftshidelyesakkqsggkvadyipqlakfspdl
wgvsvctvdgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnk
lflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqs
eresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfc
pitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmc
wsppldkmgnsvkgihfchdlvslcnfhnydnl

    Sequence, based on observed residues (ATOM records): (download) 
    >5jyoE (E:)
gsmipdfmsftshidelyesakkqsggkvadyipqlakfspdlwgvsvctvdgqrhstgd
tkvpfclqscvkplkyaiavndlgteyvhryvgkepsgnklflneddkphnpmvnagaiv
vtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqseresgdrnfaigyylkekkc
fpegtdmvgildfyfqlcsievtcesasvmaatlanggfcpitgervlspeavrntlslm
hscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcwsppldkmgnsvkgihfchd
lvslcnfhnyd

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5jyoF (F:)
mgsshhhhhhssglvprgsmipdfmsftshidelyesakkqsggkvadyipqlakfspdl
wgvsvctvdgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnk
lflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqs
eresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfc
pitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmc
wsppldkmgnsvkgihfchdlvslcnfhnydnl

    Sequence, based on observed residues (ATOM records): (download) 
    >5jyoF (F:)
gsmipdfmsftshidelyesakkqsggkvadyipqlakfspdlwgvsvctvdgqrhstgd
tkvpfclqscvkplkyaiavndlgteyvhryvgkepsgnklflneddkphnpmvnagaiv
vtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqseresgdrnfaigyylkekkc
fpegtdmvgildfyfqlcsievtcesasvmaatlanggfcpitgervlspeavrntlslm
hscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcwsppldkmgnsvkgihfchd
lvslcnfhnyd

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5jyoG (G:)
mgsshhhhhhssglvprgsmipdfmsftshidelyesakkqsggkvadyipqlakfspdl
wgvsvctvdgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnk
lflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqs
eresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfc
pitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmc
wsppldkmgnsvkgihfchdlvslcnfhnydnl

    Sequence, based on observed residues (ATOM records): (download) 
    >5jyoG (G:)
gsmipdfmsftshidelyesakkqsggkvadyipqlakfspdlwgvsvctvdgqrhstgd
tkvpfclqscvkplkyaiavndlgteyvhryvgkepsgnklflneddkphnpmvnagaiv
vtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqseresgdrnfaigyylkekkc
fpegtdmvgildfyfqlcsievtcesasvmaatlanggfcpitgervlspeavrntlslm
hscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcwsppldkmgnsvkgihfchd
lvslcnfhnyd

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5jyoH (H:)
mgsshhhhhhssglvprgsmipdfmsftshidelyesakkqsggkvadyipqlakfspdl
wgvsvctvdgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnk
lflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqs
eresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfc
pitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmc
wsppldkmgnsvkgihfchdlvslcnfhnydnl

    Sequence, based on observed residues (ATOM records): (download) 
    >5jyoH (H:)
gsmipdfmsftshidelyesakkqsggkvadyipqlakfspdlwgvsvctvdgqrhstgd
tkvpfclqscvkplkyaiavndlgteyvhryvgkepsgnklflneddkphnpmvnagaiv
vtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqseresgdrnfaigyylkekkc
fpegtdmvgildfyfqlcsievtcesasvmaatlanggfcpitgervlspeavrntlslm
hscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcwsppldkmgnsvkgihfchd
lvslcnfhnyd