PDB entry 5iev

View 5iev on RCSB PDB site
Description: Crystal structure of BAY 1000394 (Roniciclib) bound to CDK2
Class: transferase
Keywords: Antineoplastic Agents, Cyclin-Dependent Kinases, Dose-Response Relationship, Drug, Drug Discovery, HeLa Cells, Neoplasms, Protein Kinase Inhibitors, Pyrimidines, Structure-Activity Relationship, Structure-Kinetics Relationship, Sulfoxides, Biophysical Assays, Tumor, transferase
Deposited on 2016-02-25, released 2016-04-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-06-29, with a file datestamp of 2016-06-24.
Experiment type: XRAY
Resolution: 2.03 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2, CDKN2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ieva_
  • Heterogens: R0N, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ievA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >5ievA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirlgvpstaireisllkelnhpnivk
lldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlh
rdlkpqnllintegaikladfglarafgvvtlwyrapeillgckyystavdiwslgcifa
emvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvpp
ldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl