PDB entry 5hvf

View 5hvf on RCSB PDB site
Description: Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-i83)
Class: hydrolase/hydrolase inhibitor
Keywords: procarboxypeptidase U, thrombin-activatable fibrinolysis inhibitor, TAFI, procarboxypeptidase R, plasma procarboxypeptidase B, nanobody, antibody fragment, protein complex, hydrolase/hydrolase inhibitor, HYDROLASE, hydrolase-hydrolase inhibitor complex
Deposited on 2016-01-28, released 2016-06-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-08-31, with a file datestamp of 2016-08-24.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carboxypeptidase B2
    Species: Homo sapiens [TaxId:9606]
    Gene: CPB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96IY4
      • engineered mutation (304)
      • engineered mutation (328)
      • engineered mutation (332)
      • engineered mutation (334)
  • Chain 'B':
    Compound: VHH-i83
    Species: VICUGNA PACOS [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 5HVF (Start-118)
    Domains in SCOPe 2.07: d5hvfb1, d5hvfb2
  • Heterogens: NAG, BMA, MAN, ZN, FLC, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5hvfB (B:)
qvqlqesggglvqaggslrlscaasgsifspnamgwyrqapgkerelvaartnvgstyad
svkgrftvsrdnakntvylqmnslkpedtavyycnawgqdgwlgqydywgqgtqvtvss

    Sequence, based on observed residues (ATOM records): (download) 
    >5hvfB (B:)
vqlqesggglvqaggslrlscaasgsifspnamgwyrqapgkerelvaartnvgstyads
vkgrftvsrdnakntvylqmnslkpedtavyycnawgqdgwlgqydywgqgtqvtvss