PDB entry 5f2w

View 5f2w on RCSB PDB site
Description: Crystal structure of human KDM4A in complex with compound 16
Class: Oxidoreductase/Inhibitor
Keywords: Epigenetics, Demethylase, Inhibitor, Oxidoreductase-Inhibitor Complex
Deposited on 2015-12-02, released 2016-01-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-03-09, with a file datestamp of 2016-03-04.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5f2wa_
  • Chain 'B':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5f2wb_
  • Chain 'C':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5f2wc_
  • Chain 'D':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5f2wd_
  • Heterogens: ZN, 5UP, EDO, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5f2wA (A:)
smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >5f2wA (A:)
npsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddlvip
apiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknltfn
ppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwktsfawh
tedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlispl
mlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcsv
kismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5f2wB (B:)
smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >5f2wB (B:)
sesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddi
ddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkyw
knltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwk
tsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkm
tlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkq
avlcscrmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5f2wC (C:)
smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >5f2wC (C:)
etlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddl
vipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknl
tfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwktsf
awhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtli
splmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavl
cscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5f2wD (D:)
smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >5f2wD (D:)
setlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddidd
lvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywkn
ltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwkts
fawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtl
isplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqav
lcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl