PDB entry 5ecx

View 5ecx on RCSB PDB site
Description: Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(6-(pyridin-4-yl)benzo[d][1,3]dioxol-4-yl)but-1-yn-1-yl)pyrimidine-2,4-diamine
Class: OXIDOREDUCTASE/OXIDOREDUCTASE Inhibitor
Keywords: Antifolates, dfrA1, plasmid borne resistance, OXIDOREDUCTASE-OXIDOREDUCTASE Inhibitor complex
Deposited on 2015-10-20, released 2016-05-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dehydrofolate reductase type I
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: dfrA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ecxa_
  • Chain 'B':
    Compound: Dehydrofolate reductase type I
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: dfrA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ecxb_
  • Heterogens: NAP, 5N1, GOL, GLV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5ecxA (A:)
mklslmvaiskngvigngpdipwsakgeqllfkaitynqwllvgrktfesmgalpnrkya
vvtrssftsdnenvlifpsikdaltnlkkitdhvivsgggeiykslidqvdtlhistidi
epegdvyfpeipsnfrpvftqdfasninysyqiwqkg

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5ecxB (B:)
mklslmvaiskngvigngpdipwsakgeqllfkaitynqwllvgrktfesmgalpnrkya
vvtrssftsdnenvlifpsikdaltnlkkitdhvivsgggeiykslidqvdtlhistidi
epegdvyfpeipsnfrpvftqdfasninysyqiwqkg