PDB entry 5cir

View 5cir on RCSB PDB site
Description: Crystal structure of death receptor 4 (DR4; TNFFRSF10A) bound to TRAIL (TNFSF10)
Class: apoptosis
Keywords: Apoptosis, binding and specificity, ligand-receptor complex, TNF receptor family
Deposited on 2015-07-13, released 2017-01-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-01-18, with a file datestamp of 2017-01-13.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tumor necrosis factor ligand superfamily member 10
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF10, APO2L, TRAIL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5cira_
  • Chain 'B':
    Compound: Tumor necrosis factor ligand superfamily member 10
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF10, APO2L, TRAIL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5cirb_
  • Chain 'D':
    Compound: Tumor necrosis factor ligand superfamily member 10
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF10, APO2L, TRAIL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5cird_
  • Chain 'E':
    Compound: Tumor necrosis factor receptor superfamily member 10A
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFRSF10A, APO2, DR4, TRAILR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00220
      • variant (16)
      • variant (84)
  • Chain 'F':
    Compound: Tumor necrosis factor receptor superfamily member 10A
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFRSF10A, APO2, DR4, TRAILR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00220
      • variant (16)
      • variant (84)
  • Chain 'G':
    Compound: Tumor necrosis factor receptor superfamily member 10A
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFRSF10A, APO2, DR4, TRAILR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00220
      • variant (16)
      • variant (84)
  • Heterogens: ZN, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5cirA (A:)
mvrergpqrvaahitgtrgrsntlsspnsknekalgrkinswessrsghsflsnlhlrng
elvihekgfyyiysqtyfrfqeeikentkndkqmvqyiykytsypdpillmksarnscws
kdaeyglysiyqggifelkendrifvsvtnehlidmdheasffgaflvg

    Sequence, based on observed residues (ATOM records): (download) 
    >5cirA (A:)
pqrvaahitgtrekalgrkinswessrsghsflsnlhlrngelvihekgfyyiysqtyfr
fqeeikentkndkqmvqyiykytsypdpillmksarnscwskdaeyglysiyqggifelk
endrifvsvtnehlidmdheasffgaflv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5cirB (B:)
mvrergpqrvaahitgtrgrsntlsspnsknekalgrkinswessrsghsflsnlhlrng
elvihekgfyyiysqtyfrfqeeikentkndkqmvqyiykytsypdpillmksarnscws
kdaeyglysiyqggifelkendrifvsvtnehlidmdheasffgaflvg

    Sequence, based on observed residues (ATOM records): (download) 
    >5cirB (B:)
pqrvaahitgtrgekalgrkinswessrsghsflsnlhlrngelvihekgfyyiysqtyf
rfqeeikentkndkqmvqyiykytsypdpillmksarnscwskdaeyglysiyqggifel
kendrifvsvtnehlidmdheasffgaflvg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5cirD (D:)
mvrergpqrvaahitgtrgrsntlsspnsknekalgrkinswessrsghsflsnlhlrng
elvihekgfyyiysqtyfrfqeeikentkndkqmvqyiykytsypdpillmksarnscws
kdaeyglysiyqggifelkendrifvsvtnehlidmdheasffgaflvg

    Sequence, based on observed residues (ATOM records): (download) 
    >5cirD (D:)
pqrvaahitgtrekalgrkinswessrsghsflsnlhlrngelvihekgfyyiysqtyfr
fqeeikentkndkqmvqyiykytsypdpillmksarnscwskdaeyglysiyqggifelk
endrifvsvtnehlidmdheasffgaflvg

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.