PDB entry 4y6g

View 4y6g on RCSB PDB site
Description: Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with N-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F) inhibitor in the alpha-site and beta-site.
Class: lyase/lyase inhibitor
Keywords: lyase, tryptophan biosynthesis, Salmonella typhimurium, F6F, inhibitor, allosteric enzyme, aromatic amino acid biosynthesis, pyridoxal phosphate, LYASE-LYASE INHIBITOR complex
Deposited on 2015-02-13, released 2016-02-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tryptophan synthase alpha chain
    Species: Salmonella enterica subsp. enterica serovar Typhimurium [TaxId:90371]
    Gene: trpA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4y6ga_
  • Chain 'B':
    Compound: tryptophan synthase beta chain
    Species: Salmonella enterica subsp. enterica serovar Typhimurium [TaxId:90371]
    Gene: TrpB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4y6gb_
  • Heterogens: F6F, PLP, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4y6gA (A:)
meryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdplad
gptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceq
vgvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllsrs
gvtgaenrgalplhhlieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivki
ieknlaspkqmlaelrsfvsamkaasra

    Sequence, based on observed residues (ATOM records): (download) 
    >4y6gA (A:)
meryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdplad
gptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceq
vgvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllsrs
glhhlieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivkiieknlaspkqm
laelrsfvsamkaasra

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4y6gB (B:)
mttllnpyfgefggmyvpqilmpalnqleeafvsaqkdpefqaqfadllknyagrptalt
kcqnitagtrttlylkredllhggahktnqvlgqallakrmgkseiiaetgagqhgvasa
lasallglkcriymgakdverqspnvfrmrlmgaevipvhsgsatlkdacnealrdwsgs
yetahymlgtaagphpyptivrefqrmigeetkaqildkegrlpdaviacvgggsnaigm
fadfindtsvgligvepgghgietgehgaplkhgrvgiyfgmkapmmqtadgqieesysi
sagldfpsvgpqhaylnsigradyvsitddealeafktlcrhegiipalesshalahalk
mmreqpekeqllvvnlsgrgdkdiftvhdilkargei

    Sequence, based on observed residues (ATOM records): (download) 
    >4y6gB (B:)
ttllnpyfgefggmyvpqilmpalnqleeafvsaqkdpefqaqfadllknyagrptaltk
cqnitagtrttlylkredllhggahktnqvlgqallakrmgkseiiaetgagqhgvasal
asallglkcriymgakdverqspnvfrmrlmgaevipvhsgsatlkdacnealrdwsgsy
etahymlgtaagphpyptivrefqrmigeetkaqildkegrlpdaviacvgggsnaigmf
adfindtsvgligvepgghgietgehgaplkhgrvgiyfgmkapmmqtadgqieesysis
agldfpsvgpqhaylnsigradyvsitddealeafktlcrhegiipalesshalahalkm
mreqpekeqllvvnlsgrgdkdiftvhdilkargei