PDB entry 4wym

View 4wym on RCSB PDB site
Description: Structural basis of HIV-1 capsid recognition by CPSF6
Class: viral protein
Keywords: CAPSID PROTEIN, HEXAMER, ENGINEERED DISULFIDE BONDS, VIRAL PROTEIN, CPSF6, viral restriction
Deposited on 2014-11-17, released 2014-12-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (183-184)
    Domains in SCOPe 2.07: d4wyma1, d4wyma2
  • Chain 'B':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (183-184)
    Domains in SCOPe 2.07: d4wymb1, d4wymb2
  • Chain 'C':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (183-184)
    Domains in SCOPe 2.07: d4wymc1, d4wymc2
  • Chain 'D':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (183-184)
    Domains in SCOPe 2.07: d4wymd1, d4wymd2
  • Chain 'E':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (183-184)
    Domains in SCOPe 2.07: d4wyme1, d4wyme2
  • Chain 'F':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (183-184)
    Domains in SCOPe 2.07: d4wymf1, d4wymf2
  • Chain 'G':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (184)
    Domains in SCOPe 2.07: d4wymg1, d4wymg2
  • Chain 'H':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (184)
    Domains in SCOPe 2.07: d4wymh1, d4wymh2
  • Chain 'I':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (183-184)
    Domains in SCOPe 2.07: d4wymi1
  • Chain 'J':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (183-184)
    Domains in SCOPe 2.07: d4wymj1, d4wymj2
  • Chain 'K':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (183-184)
    Domains in SCOPe 2.07: d4wymk1, d4wymk2
  • Chain 'L':
    Compound: capsid protein p24
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11698]
    Gene: GAG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12497 (0-End)
      • engineered mutation (13)
      • engineered mutation (44)
      • engineered mutation (183-184)
    Domains in SCOPe 2.07: d4wyml1
  • Chain 'M':
    Compound: isoform 2 of cleavage and polyadenylation specificity factor subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF6, CFIM68
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: isoform 2 of cleavage and polyadenylation specificity factor subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF6, CFIM68
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16630 (2-End)
      • expression tag (1)
  • Chain 'O':
    Compound: isoform 2 of cleavage and polyadenylation specificity factor subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF6, CFIM68
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: isoform 2 of cleavage and polyadenylation specificity factor subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF6, CFIM68
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16630 (2-End)
      • expression tag (1)
  • Chain 'Q':
    Compound: isoform 2 of cleavage and polyadenylation specificity factor subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF6, CFIM68
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: isoform 2 of cleavage and polyadenylation specificity factor subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF6, CFIM68
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16630 (2-End)
      • expression tag (1)
  • Chain 'S':
    Compound: isoform 2 of cleavage and polyadenylation specificity factor subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF6, CFIM68
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16630 (2-End)
      • expression tag (0-1)
  • Chain 'T':
    Compound: isoform 2 of cleavage and polyadenylation specificity factor subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF6, CFIM68
    Database cross-references and differences (RAF-indexed):
  • Chain 'U':
    Compound: isoform 2 of cleavage and polyadenylation specificity factor subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF6, CFIM68
    Database cross-references and differences (RAF-indexed):
  • Chain 'V':
    Compound: isoform 2 of cleavage and polyadenylation specificity factor subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF6, CFIM68
    Database cross-references and differences (RAF-indexed):
  • Chain 'W':
    Compound: isoform 2 of cleavage and polyadenylation specificity factor subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSF6, CFIM68
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wymA (A:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymA (A:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqnaat
etllvqnanpdcktilkalgpgatleemmtacqg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4wymB (B:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymB (B:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvgqmreprgsdiagttstlqeqigwmthnppipvg
eiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqevknaate
tllvqnanpdcktilkalgpgatleemmtacqg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4wymC (C:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymC (C:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvgqmreprgsdiagttstlqeqigwmthnppipvg
eiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqevknaate
tllvqnanpdcktilkalgpgatleemmtacq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4wymD (D:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymD (D:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvpgqmreprgsdiagttstlqeqigwmthnppipv
geiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqaatetllvqn
anpdcktilkalgatleemmtacq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4wymE (E:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymE (E:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpiapgqmreprgsdiagttstlqeqigwmthnppip
vgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqevknaa
tetllvqnanpdcktilkalgpgatleemmtacqg

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4wymF (F:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymF (F:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqg

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4wymG (G:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymG (G:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqatet
llvqnanpdcktilkalgpgatleemmtacq

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4wymH (H:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymH (H:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqatet
llvqnanpdcktilkalgpgatleemmtacq

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >4wymI (I:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymI (I:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqaate
tllvqnanpdcktilkalgpgatleemmtacq

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >4wymJ (J:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymJ (J:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvpgqmreprgsdiagttstlqeqigwmthnppipv
geiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqevknaat
etllvqnanpdcktilkalgpgatleemmtacq

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >4wymK (K:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymK (K:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhppiapgqmreprgsdiagttstlqeqigwmthnppi
pvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqknaatetl
lvqnanpdcktilkalgpgatleemmtacq

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4wymL (L:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvhagpiapgqmreprgsdiagttstlqeqigwmth
nppipvgeiykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqasqe
vknaatetllvqnanpdcktilkalgpgatleemmtacqgvggpghkarvl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wymL (L:)
pivqnlqgqmvhqcisprtlnawvkvveekafspevipmfsalscgatpqdlntmlntvg
ghqaamqmlketineeaaewdrlhpvmreprgsdiagttstlqeqigwmthnppipvgei
ykrwiilglnkivrmysptsildirqgpkepfrdyvdrfyktlraeqqevknaatetllv
qnanpdcktilkalgpgatleemmtacq

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.

  • Chain 'R':
    No sequence available.

  • Chain 'S':
    No sequence available.

  • Chain 'T':
    No sequence available.

  • Chain 'U':
    No sequence available.

  • Chain 'V':
    No sequence available.

  • Chain 'W':
    No sequence available.