PDB entry 4wvf
View 4wvf on RCSB PDB site
Description: Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1
Class: transport protein/transport protein inhibitor
Keywords: CRM1, inhibitor, SINE, KPT, TRANSPORT PROTEIN-TRANSPORT PROTEIN INHIBITOR complex
Deposited on
2014-11-05, released
2015-07-15
The last revision prior to the SCOPe 2.07 freeze date was dated
2015-07-15, with a file datestamp of
2015-07-10.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTP-binding nuclear protein ran
Species: Homo sapiens [TaxId:9606]
Gene: RAN, ARA24, OK/SW-cl.81
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d4wvfa_ - Chain 'B':
Compound: Ran-specific GTPase-activating protein 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d4wvfb_ - Chain 'C':
Compound: Crm1p
Species: Saccharomyces cerevisiae [TaxId:1182966]
Gene: Crm1, R008_G21866
Database cross-references and differences (RAF-indexed):
- Uniprot W7PTE1 (3-End)
- expression tag (1-2)
- engineered mutation (504)
- cloning artifact (987)
- Heterogens: GNP, MG, EDO, GOL, K76, CL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4wvfA (A:)
maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
alappevvmdpalaaqyehdlevaqttalpdedddl
Sequence, based on observed residues (ATOM records): (download)
>4wvfA (A:)
qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
vmdpalaaqyehdlevaqttalpdedddl
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4wvfB (B:)
dihfepvvhlekvdvktmeedeevlykvraklfrfdadakewkergtgdckflknkktnk
vrilmrrdktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgsk
enadkfkeefekaqeinkka
Sequence, based on observed residues (ATOM records): (download)
>4wvfB (B:)
ihfepvvtmeedeevlykvraklfrfdadakewkergtgdckflknkktnkvrilmrrdk
tlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgskenadkfkee
fekaqeinkk
- Chain 'C':
No sequence available.