PDB entry 4wmc

View 4wmc on RCSB PDB site
Description: OXA-48 covalent complex with Avibactam inhibitor
Class: hydrolase
Keywords: OXA-48, Class D carbapenemase, Avibactam, inhibitor, hydrolase
Deposited on 2014-10-08, released 2014-12-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-06-03, with a file datestamp of 2015-05-29.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4wmca_
  • Chain 'B':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4wmcb_
  • Chain 'C':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4wmcc_
  • Chain 'D':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4wmcd_
  • Chain 'E':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4wmce_
  • Chain 'F':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4wmcf_
  • Chain 'G':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4wmcg_
  • Chain 'H':
    Compound: Beta-lactamase
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla OXA-48, blaOXA-48, KPE71T_00045
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4wmch_
  • Heterogens: NXL, CO2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wmcA (A:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

    Sequence, based on observed residues (ATOM records): (download) 
    >4wmcA (A:)
ewqenkswnahfqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdlgvvkd
ehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafdygned
isgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdyiirak
tgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqekiip

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4wmcB (B:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

    Sequence, based on observed residues (ATOM records): (download) 
    >4wmcB (B:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnesfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdyiiraktg
ystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqekiip

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4wmcC (C:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

    Sequence, based on observed residues (ATOM records): (download) 
    >4wmcC (C:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafdygned
idsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdyiiraktgys
epkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqekiip

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4wmcD (D:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

    Sequence, based on observed residues (ATOM records): (download) 
    >4wmcD (D:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedifwldggirisateqisflrklyhnklhvsersqrivkqamlteangdyiirakt
gystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqekiip

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4wmcE (E:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

    Sequence, based on observed residues (ATOM records): (download) 
    >4wmcE (E:)
ewqenkswnahftehgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdlgvv
kdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafdygn
edisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdyiir
aktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqekiip

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4wmcF (F:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

    Sequence, based on observed residues (ATOM records): (download) 
    >4wmcF (F:)
wqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdlg
vvkdehqvfkwdgqtrdatwnrdhnlitamkysvvpvyqefarqigearmskmlhafdyg
nedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdyii
raktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqekiip

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4wmcG (G:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

    Sequence, based on observed residues (ATOM records): (download) 
    >4wmcG (G:)
wqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdlg
vvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafdy
gnedvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdyiirak
tgystepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqekiip

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4wmcH (H:)
ewqenkswnahftehksqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdl
gvvkdehqvfkwdgqtrdiatwnrdhnlitamkysvvpvyqefarqigearmskmlhafd
ygnedisgnvdsfwldggirisateqisflrklyhnklhvsersqrivkqamlteangdy
iiraktgystriepkigwwvgwvelddnvwffamnmdmptsdglglrqaitkevlkqeki
ip

    Sequence, based on observed residues (ATOM records): (download) 
    >4wmcH (H:)
wqenkswnahfqgvvvlwnenkqqgftnnlkranqaflpastfkipnslialdlgvvkde
hqvfkrdhnlitamkysvvpvyqefarqigearmskmlhafdygnedivdsfwldggiri
sateqisflrklyhnklhvsersqrivkqamlteangdyiiraktgystriepkigwwvg
wvelddnvwffamnmdmptsdglglrqaitkevlkqekiip