PDB entry 4wi8
View 4wi8 on RCSB PDB site
Description: Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation Y436A
Class: immune system
Keywords: Human IgG1, FcRn binding site, Therapeutic antibody, IMMUNE SYSTEM
Deposited on
2014-09-25, released
2015-09-30
The last revision prior to the SCOPe 2.07 freeze date was dated
2017-09-13, with a file datestamp of
2017-09-08.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.15
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Ig gamma-1 chain C region
Species: Homo sapiens [TaxId:9606]
Gene: IGHG1
Database cross-references and differences (RAF-indexed):
- Uniprot P01857 (0-207)
- engineered mutation (199)
Domains in SCOPe 2.07: d4wi8a1, d4wi8a2 - Chain 'B':
Compound: Ig gamma-1 chain C region
Species: Homo sapiens [TaxId:9606]
Gene: IGHG1
Database cross-references and differences (RAF-indexed):
- Uniprot P01857 (0-207)
- engineered mutation (199)
Domains in SCOPe 2.07: d4wi8b1, d4wi8b2 - Heterogens: NAG, BMA, MAN, FUC, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4wi8A (A:)
gpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqy
nstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsrd
eltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksr
wqqgnvfscsvmhealhnhatqkslsls
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4wi8B (B:)
gpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqy
nstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsrd
eltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksr
wqqgnvfscsvmhealhnhatqkslsls