PDB entry 4w9k
View 4w9k on RCSB PDB site
Description: pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-3-phenylpropanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 14)
Class: transcription
Keywords: protein complex, ubiquitin ligase, hypoxia inducible factor, transcription
Deposited on
2014-08-27, released
2014-09-10
The last revision prior to the SCOPe 2.04 freeze date was dated
2014-09-10, with a file datestamp of
2014-09-05.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.217
AEROSPACI score: 0.32
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transcription elongation factor B polypeptide 2
Species: Homo sapiens [TaxId:9606]
Gene: TCEB2
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: Transcription elongation factor B polypeptide 1
Species: Homo sapiens [TaxId:9606]
Gene: TCEB1
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: von hippel-lindau disease tumor suppressor
Species: Homo sapiens [TaxId:9606]
Gene: VHL
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4w9kc_ - Chain 'D':
Compound: Transcription elongation factor B polypeptide 2
Species: Homo sapiens [TaxId:9606]
Gene: TCEB2
Database cross-references and differences (RAF-indexed):
- Chain 'E':
Compound: Transcription elongation factor B polypeptide 1
Species: Homo sapiens [TaxId:9606]
Gene: TCEB1
Database cross-references and differences (RAF-indexed):
- Chain 'F':
Compound: von hippel-lindau disease tumor suppressor
Species: Homo sapiens [TaxId:9606]
Gene: VHL
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4w9kf_ - Chain 'G':
Compound: Transcription elongation factor B polypeptide 2
Species: Homo sapiens [TaxId:9606]
Gene: TCEB2
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: Transcription elongation factor B polypeptide 1
Species: Homo sapiens [TaxId:9606]
Gene: TCEB1
Database cross-references and differences (RAF-indexed):
- Chain 'I':
Compound: von hippel-lindau disease tumor suppressor
Species: Homo sapiens [TaxId:9606]
Gene: VHL
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4w9ki_ - Chain 'J':
Compound: Transcription elongation factor B polypeptide 2
Species: Homo sapiens [TaxId:9606]
Gene: TCEB2
Database cross-references and differences (RAF-indexed):
- Chain 'K':
Compound: Transcription elongation factor B polypeptide 1
Species: Homo sapiens [TaxId:9606]
Gene: TCEB1
Database cross-references and differences (RAF-indexed):
- Uniprot Q15369 (1-96)
- initiating methionine (0)
- Chain 'L':
Compound: von hippel-lindau disease tumor suppressor
Species: Homo sapiens [TaxId:9606]
Gene: VHL
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4w9kl_ - Heterogens: 3JO, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence, based on SEQRES records: (download)
>4w9kC (C:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd
Sequence, based on observed residues (ATOM records): (download)
>4w9kC (C:)
vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
rslyedledhpnvqkdlerlt
- Chain 'D':
No sequence available.
- Chain 'E':
No sequence available.
- Chain 'F':
Sequence, based on SEQRES records: (download)
>4w9kF (F:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd
Sequence, based on observed residues (ATOM records): (download)
>4w9kF (F:)
vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
rslyedledhpnvqkdlerltqer
- Chain 'G':
No sequence available.
- Chain 'H':
No sequence available.
- Chain 'I':
Sequence, based on SEQRES records: (download)
>4w9kI (I:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd
Sequence, based on observed residues (ATOM records): (download)
>4w9kI (I:)
vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
slyedledhpnvqkdlerltqe
- Chain 'J':
No sequence available.
- Chain 'K':
No sequence available.
- Chain 'L':
Sequence, based on SEQRES records: (download)
>4w9kL (L:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd
Sequence, based on observed residues (ATOM records): (download)
>4w9kL (L:)
vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
rslyedledhpnvqkdlerltqe